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GPCR

Name	Alpha-2C adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA2C
Synonym	alpha2-C4 Adra-2c ADRA2L2 ADRA2RL2 Adrenergic alpha2C- receptor class I adrenergic receptor alpha-2 adrenergic receptor subtype C4 alpha2C-adrenoceptor alpha-2C adrenergic receptor Alpha-2C adrenoceptor alpha-2C adrenoreceptor Alpha-2CAR [ Show all ]
Disease	Diabetic nephropathy; Fibromyalgia Hypertension Heart failure Glaucoma Alzheimer disease Asthma Erythema Contusion Depression Hypotension Male sexual disorders Neurological disease Obesity Ocular disease Allergic rhinitis Alcohol use disorders Ocular hypertension Poison intoxication Peptic ulcer Pain [ Show all ]
Length	462
Amino acid sequence	MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
UniProt	P18825
Protein Data Bank	N/A
GPCR-HGmod model	P18825
3D structure model	This predicted structure model is from GPCR-EXP P18825.
BioLiP	N/A
Therapeutic Target Database	T01777
ChEMBL	CHEMBL1916
IUPHAR	27
DrugBank	BE0004864, BE0000342, BE0004888

Ligand

Name	ICODEXTRIN
Molecular formula	C8H8Cl2N4
IUPAC name	2-[(2,6-dichlorophenyl)methylideneamino]guanidine
Molecular weight	231.08
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	1.7
Synonyms	Tox21_110932_1 2,6-dichlorobenzaldehyde guanylhydrazone CHEMBL1313657 DSSTox_RID_81042 KBio1_000010 MRF-0000008 SPBio_001991 Spectrum4_000567 DB-051784 FT-0635524 KBio2_006459 NCGC00024846-08 SR-01000721838-5 AKOS017264577 DSSTox_CID_25666 Hydrazinecarboximidamide, 2-[(2,6-dichlorophenyl)methylene]-, (E)- KBioSS_001323 Prestwick1_000096 WDZVGELJXXEGPV-UHFFFAOYSA-N 2-[(2,6-dichlorophenyl)methylideneamino]guanidine CTK4H1147 DTXSID6045666 KBio2_001323 N-(2,6-dichlorobenzylidene)-N'-amidino hydrazine Spectrum2_001114 Spectrum_000843 DB00629 HMS2233D12 KBio3_001310 NINDS_000010 Tox21_110932 1-(2,6-Dichlorobenzylideneamino)guanidine CAS-5051-62-7 DSSTox_GSID_45666 MCULE-4615358259 SPBio_001248 Spectrum3_000445 ZINC242701441 5051-62-7 D02YCH Extraneal KBio2_003891 NCGC00024846-03 SR-01000721838 AC1L1G45 DivK1c_000010 HMS3370A17 KBioGR_000974 Prestwick0_000096 [ Show all ]
Inchi Key	WDZVGELJXXEGPV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C8H8Cl2N4/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12/h1-4H,(H4,11,12,14)
PubChem CID	3517
ChEMBL	N/A
IUPHAR	N/A
BindingDB	81979, 96725
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	446.68 nM	PMID9605427	BindingDB
Ki	446.684 nM	PMID9605427	PDSP

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