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GPCR

Name	Trace amine-associated receptor 1
Species	Homo sapiens (Human)
Gene	TAAR1
Synonym	trace amine receptor 1 TAR1 TaR-1 TA1 receptor TRAR1
Disease	N/A
Length	339
Amino acid sequence	MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS
UniProt	Q96RJ0
Protein Data Bank	N/A
GPCR-HGmod model	Q96RJ0
3D structure model	This predicted structure model is from GPCR-EXP Q96RJ0.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5857
IUPHAR	364
DrugBank	BE0001044

Ligand

Name	ICODEXTRIN
Molecular formula	C8H8Cl2N4
IUPAC name	2-[(2,6-dichlorophenyl)methylideneamino]guanidine
Molecular weight	231.08
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	1.7
Synonyms	DB-051784 FT-0635524 KBio2_006459 NCGC00024846-08 Spectrum4_000567 AKOS017264577 DSSTox_CID_25666 Hydrazinecarboximidamide, 2-[(2,6-dichlorophenyl)methylene]-, (E)- KBioSS_001323 Prestwick1_000096 SR-01000721838-5 CTK4H1147 DTXSID6045666 KBio2_001323 N-(2,6-dichlorobenzylidene)-N'-amidino hydrazine Spectrum2_001114 WDZVGELJXXEGPV-UHFFFAOYSA-N 2-[(2,6-dichlorophenyl)methylideneamino]guanidine DB00629 HMS2233D12 KBio3_001310 NINDS_000010 Spectrum_000843 CAS-5051-62-7 DSSTox_GSID_45666 MCULE-4615358259 SPBio_001248 Tox21_110932 1-(2,6-Dichlorobenzylideneamino)guanidine D02YCH Extraneal KBio2_003891 NCGC00024846-03 Spectrum3_000445 ZINC242701441 5051-62-7 AC1L1G45 DivK1c_000010 HMS3370A17 KBioGR_000974 Prestwick0_000096 SR-01000721838 CHEMBL1313657 DSSTox_RID_81042 KBio1_000010 MRF-0000008 SPBio_001991 Tox21_110932_1 2,6-dichlorobenzaldehyde guanylhydrazone [ Show all ]
Inchi Key	WDZVGELJXXEGPV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C8H8Cl2N4/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12/h1-4H,(H4,11,12,14)
PubChem CID	3517
ChEMBL	N/A
IUPHAR	N/A
BindingDB	81979, 96725
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<3327.0 nM	N/A	BindingDB
IC50	1173.0 nM	N/A	BindingDB

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