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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 7
Species	Rattus norvegicus (Rat)
Gene	Htr7
Synonym	GPRFO 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 5-HTx 5-HT7 receptor 5-HT7 5-HT1Y 5-HT-X 5-HT-7 Serotonin receptor 7 [ Show all ]
Disease	N/A for non-human GPCRs
Length	448
Amino acid sequence	MMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGFLEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVLQNSDHCGKKGHDT
UniProt	P32305
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3223
IUPHAR	12
DrugBank	N/A

Ligand

Name	2-Bromolysergic acid diethylamide
Molecular formula	C20H24BrN3O
IUPAC name	(6aR,9R)-5-bromo-N,N-diethyl-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide
Molecular weight	402.336
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	4.0
Synonyms	2-Bromo-9,10-didehydro-N,N-diethyl-6-methylergoline-8-beta-carboxamide Bromlysergamide D00VRV UNII-JUA77QEU32 AC1Q279X BROMOLYSERGIDE GTPL272 ZINC13531276 2-Br-LSD 478-84-2 BOL-148 D-2-Brom-diethylamide of lysergic acid LSD,2-Bromo 2-Bromo-D-lysergic acid diethylamide 9,10-Didehydro-N,N-diethyl-2-bromo-6-methylergoline-8-beta-carboxamide Bromo-LSD Ergoline-8-beta-carboxamide, 2-bromo-9,10-didehydro-N,N-diethyl-6-methyl- USAF SZ-1 (6aR,9R)-5-Bromo-7-methyl-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinoline-9-carboxylic acid diethylamide 2-bromolysergic acid diethylamide, BOL-148 BDBM50130269 JUA77QEU32 2-Brom-D-lysergic acid diethylamine 5-Bromo-7-methyl-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinoline-9-carboxylic acid diethylamide Brom LSD D-2-Bromolysergic acid diethylamide SCHEMBL1883414 2-Bromo-LSD AC1L1UNB Bromolysergic acid diethylamide Ergoline-8-carboxamide, 2-bromo-9,10-didehydro-N,N-diethyl-6-methyl-, (8beta)- VKRAXSZEDRWLAG-SJKOYZFVSA-N (6aR,9R)-5-bromo-N,N-diethyl-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide BOL CHEMBL274384 LS-64332 [ Show all ]
Inchi Key	VKRAXSZEDRWLAG-SJKOYZFVSA-N
Inchi ID	InChI=1S/C20H24BrN3O/c1-4-24(5-2)20(25)12-9-14-13-7-6-8-16-18(13)15(19(21)22-16)10-17(14)23(3)11-12/h6-9,12,17,22H,4-5,10-11H2,1-3H3/t12-,17-/m1/s1
PubChem CID	10171
ChEMBL	CHEMBL274384
IUPHAR	272
BindingDB	50130269
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	10.0 nM	PMID10843226	BindingDB,ChEMBL

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