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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 5A
Species	Homo sapiens (Human)
Gene	HTR5A
Synonym	5-HT5alpha 5-HT-5 MR22 Htr5 5-HT-5A 5-HT5A 5HT5- 5-HT5A receptor 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled serotonin receptor 5A [ Show all ]
Disease	N/A
Length	357
Amino acid sequence	MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH
UniProt	P47898
Protein Data Bank	N/A
GPCR-HGmod model	P47898
3D structure model	This predicted structure model is from GPCR-EXP P47898.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3426
IUPHAR	10
DrugBank	BE0004688

Ligand

Name	2-Bromolysergic acid diethylamide
Molecular formula	C20H24BrN3O
IUPAC name	(6aR,9R)-5-bromo-N,N-diethyl-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide
Molecular weight	402.336
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	4.0
Synonyms	AC1Q279X BROMOLYSERGIDE GTPL272 ZINC13531276 BOL-148 D-2-Brom-diethylamide of lysergic acid LSD,2-Bromo 2-Br-LSD 478-84-2 9,10-Didehydro-N,N-diethyl-2-bromo-6-methylergoline-8-beta-carboxamide Bromo-LSD Ergoline-8-beta-carboxamide, 2-bromo-9,10-didehydro-N,N-diethyl-6-methyl- USAF SZ-1 2-Bromo-D-lysergic acid diethylamide BDBM50130269 JUA77QEU32 (6aR,9R)-5-Bromo-7-methyl-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinoline-9-carboxylic acid diethylamide 2-bromolysergic acid diethylamide, BOL-148 Brom LSD D-2-Bromolysergic acid diethylamide SCHEMBL1883414 2-Brom-D-lysergic acid diethylamine 5-Bromo-7-methyl-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinoline-9-carboxylic acid diethylamide AC1L1UNB Bromolysergic acid diethylamide Ergoline-8-carboxamide, 2-bromo-9,10-didehydro-N,N-diethyl-6-methyl-, (8beta)- VKRAXSZEDRWLAG-SJKOYZFVSA-N 2-Bromo-LSD BOL CHEMBL274384 LS-64332 (6aR,9R)-5-bromo-N,N-diethyl-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide Bromlysergamide D00VRV UNII-JUA77QEU32 2-Bromo-9,10-didehydro-N,N-diethyl-6-methylergoline-8-beta-carboxamide [ Show all ]
Inchi Key	VKRAXSZEDRWLAG-SJKOYZFVSA-N
Inchi ID	InChI=1S/C20H24BrN3O/c1-4-24(5-2)20(25)12-9-14-13-7-6-8-16-18(13)15(19(21)22-16)10-17(14)23(3)11-12/h6-9,12,17,22H,4-5,10-11H2,1-3H3/t12-,17-/m1/s1
PubChem CID	10171
ChEMBL	CHEMBL274384
IUPHAR	272
BindingDB	50130269
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	>10.0 nM	PMID12825922	BindingDB,ChEMBL

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