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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	G-protein coupled receptor 4
Species	Homo sapiens (Human)
Gene	GPR4
Synonym	G-protein coupled receptor 19 GPR19 GPR4
Disease	N/A
Length	362
Amino acid sequence	MGNHTWEGCHVDSRVDHLFPPSLYIFVIGVGLPTNCLALWAAYRQVQQRNELGVYLMNLSIADLLYICTLPLWVDYFLHHDNWIHGPGSCKLFGFIFYTNIYISIAFLCCISVDRYLAVAHPLRFARLRRVKTAVAVSSVVWATELGANSAPLFHDELFRDRYNHTFCFEKFPMEGWVAWMNLYRVFVGFLFPWALMLLSYRGILRAVRGSVSTERQEKAKIKRLALSLIAIVLVCFAPYHVLLLSRSAIYLGRPWDCGFEERVFSAYHSSLAFTSLNCVADPILYCLVNEGARSDVAKALHNLLRFLASDKPQEMANASLTLETPLTSKRNSTAKAMTGSWAATPPSQGDQVQLKMLPPAQ
UniProt	P46093
Protein Data Bank	N/A
GPCR-HGmod model	P46093
3D structure model	This predicted structure model is from GPCR-EXP P46093.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3638324
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL3675740
Molecular formula	C25H31N7
IUPAC name	2-ethyl-5,7-dimethyl-3-[[4-[4-(piperazin-1-ylmethyl)pyrazol-1-yl]phenyl]methyl]pyrazolo[1,5-a]pyrimidine
Molecular weight	429.572
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	3.0
Synonyms	US8748435, 31 BDBM123506 SCHEMBL12802445
Inchi Key	VHXUBUZJOSUAFP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H31N7/c1-4-24-23(25-28-18(2)13-19(3)32(25)29-24)14-20-5-7-22(8-6-20)31-17-21(15-27-31)16-30-11-9-26-10-12-30/h5-8,13,15,17,26H,4,9-12,14,16H2,1-3H3
PubChem CID	68379041
ChEMBL	CHEMBL3675740
IUPHAR	N/A
BindingDB	123506
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	43.0 nM	, None	BindingDB,ChEMBL

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