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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H4 receptor
Species	Homo sapiens (Human)
Gene	HRH4
Synonym	Pfi-013 SP9144 HH4R H4R H4 receptor GPRv53 GPCR105 G-protein coupled receptor 105 AXOR35 [ Show all ]
Disease	Allergic rhinitis Asthma Inflammatory disease Rheumatoid arthritis
Length	390
Amino acid sequence	MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
UniProt	Q9H3N8
Protein Data Bank	N/A
GPCR-HGmod model	Q9H3N8
3D structure model	This predicted structure model is from GPCR-EXP Q9H3N8.
BioLiP	N/A
Therapeutic Target Database	T26500
ChEMBL	CHEMBL3759
IUPHAR	265
DrugBank	BE0000146

Ligand

Name	CHEMBL3236553
Molecular formula	C13H21N5
IUPAC name	4-cyclopentyl-6-piperazin-1-ylpyrimidin-2-amine
Molecular weight	247.346
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	1.3
Synonyms	4-cyclopentyl-6-(piperazin-1-yl)-pyrimidin-2-ylamine BDBM50006742 SCHEMBL604826 4-Cyclopentyl-6-piperazin-1-yl-pyrimidin-2-ylamine 1013105-41-3 UYXWQSZIUMRFIW-UHFFFAOYSA-N [ Show all ]
Inchi Key	UYXWQSZIUMRFIW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H21N5/c14-13-16-11(10-3-1-2-4-10)9-12(17-13)18-7-5-15-6-8-18/h9-10,15H,1-8H2,(H2,14,16,17)
PubChem CID	24798144
ChEMBL	CHEMBL3236553
IUPHAR	N/A
BindingDB	50006742
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<10000.0 nM	PMID24495018	BindingDB,ChEMBL
Kd	0.3162 nM	PMID24495018	ChEMBL
Ki	1.0 nM	PMID25455490	ChEMBL
Ki	1.0 nM	PMID25455490	BindingDB
Ki	1.2 nM	PMID24495018	BindingDB,ChEMBL

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