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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 1A
Species	Mus musculus (Mouse)
Gene	Htr1a
Synonym	5-HT-1A Gpcr18 ADRBRL1 ADRB2RL1 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 5-HT1A receptor 5-HT1A Serotonin receptor 1A [ Show all ]
Disease	N/A for non-human GPCRs
Length	421
Amino acid sequence	MDMFSLGQGNNTTTSLEPFGTGGNDTGLSNVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSNPNECTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKKGAGTSFGTSSAPPPKKSLNGQPGSGDCRRSAENRAVGTPCANGAVRQGEDDATLEVIEVHRVGNSKGHLPLPSESGATSYVPACLERKNERTAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPELLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCR
UniProt	Q64264
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3737
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	Ifenprodil
Molecular formula	C21H27NO2
IUPAC name	4-[2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol
Molecular weight	325.452
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	3.9
Synonyms	UYNVMODNBIQBMV-UHFFFAOYSA-N 4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol Alpha 1-PI CCG-204747 D0I0DL FT-0601591 ifenprodil tartrate LS-115339 NCGC00024643-10 SCHEMBL34010 1-Piperidineethanol, alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenylmethyl)- (9CI) 210I562 4-[2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol BDBM50083351 CHEMBL305187 DSSTox_CID_25656 I06-0297 Ifenprodilum NCGC00024643-03 PDSP2_000646 (+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol] SR-01000075169-11 Tox21_110915_1 4-(2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl)phenol AC1L1GHT CAS-23210-56-2 D08064 DTXSID2045656 IFENPRODIL HEMITARTRATE KB-52538 NCGC00024643-06 RC-61-91 1-Piperidineethanol, 4-benzyl-alpha-(p-hydroxyphenyl)-beta-methyl- 2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-2-methyl-1-ethanol Vadilex 4-[2-(4-Benzyl-1-piperidyl)-1-hydroxy-propyl]phenol; (2R,3R)-2,3-dihydroxybutanedioic acid alpha-(4-Hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidine ethanol CHEBI:93829 DB08954 GTPL5472 Ifenprodil tartrate salt MRF-0000097 NCGC00024643-12 SR-01000075169 23210-56-2 61 91 RC BRD-A24191444-045-03-1 ChEMBL_104385 DSSTox_GSID_45656 Ifenprodilum [INN-Latin] NCGC00024643-04 R8OE3P6O5S (plusmn)-ifenprodil SR-01000075169-3 UNII-R8OE3P6O5S 4-Benzyl-alpha-(p-hydroxyphenyl)-beta-methyl-1-piperidineethanol AKOS015895174 CC-29467 D08VCI EINECS 245-491-4 Ifenprodil L-(+)-tartrate L005364 NCGC00024643-07 SBI-0050640.P002 1-Piperidineethanol, alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenylmethyl)- 2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)propanol 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy-propyl]-phenol AX8042605 Dilvax HMS2089G05 Ifenprodil [INN:DCF] NCGC00024643-02 PDSP1_000654 SR-01000075169-1 Tox21_110915 23210-58-4 925913-11-7 C-19841 Creocral DSSTox_RID_81034 Ifenprodil (INN) J-015034 NCGC00024643-05 RC 61-91 1-Methyl-2-hydroxy-2-(4-hydroxyphenyl)ethyl-1-(4-benzylpiperidine) [ Show all ]
Inchi Key	UYNVMODNBIQBMV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3
PubChem CID	3689
ChEMBL	CHEMBL305187
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	238.0 nM	PMID1681106	ChEMBL

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