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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	G-protein coupled receptor 183
Species	Homo sapiens (Human)
Gene	GPR183
Synonym	EBI2 {ECO:0000303\|PubMed:8383238} lymphocyte-specific G protein-coupled receptor hEBI2 {ECO:0000303\|PubMed:22875855} GPR183 G protein-coupled receptor 183 EBI2 Epstein-Barr virus-induced G-protein coupled receptor 2 {ECO:0000303\|PubMed:8383238} EBV-induced G-protein coupled receptor 2 {ECO:0000303\|PubMed:8383238} EBV-induced G protein-coupled receptor 2 Epstein-Barr virus-induced gene 2 [ Show all ]
Disease	N/A
Length	361
Amino acid sequence	MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVNFMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERITCMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNGK
UniProt	P32249
Protein Data Bank	N/A
GPCR-HGmod model	P32249
3D structure model	This predicted structure model is from GPCR-EXP P32249.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3259470
IUPHAR	81
DrugBank	N/A

Ligand

Name	CHEMBL3262884
Molecular formula	C22H24N2O3
IUPAC name	(E)-3-(4-methoxyphenyl)-1-[4-(3-methylbenzoyl)piperazin-1-yl]prop-2-en-1-one
Molecular weight	364.445
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	3.1
Synonyms	BDBM50011726 (E)-3-(4-methoxyphenyl)-1-[4-(3-methylbenzoyl)piperazin-1-yl]prop-2-en-1-one
Inchi Key	UTJGAMJRQCMZJM-DHZHZOJOSA-N
Inchi ID	InChI=1S/C22H24N2O3/c1-17-4-3-5-19(16-17)22(26)24-14-12-23(13-15-24)21(25)11-8-18-6-9-20(27-2)10-7-18/h3-11,16H,12-15H2,1-2H3/b11-8+
PubChem CID	86579940
ChEMBL	CHEMBL3262884
IUPHAR	N/A
BindingDB	50011726
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	29.51 nM	PMID24678947	ChEMBL
IC50	30.0 nM	PMID24678947	BindingDB
IC50	31.0 nM	PMID24678947	ChEMBL

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