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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	5-Nitro-2-p-tolyl-1H-benzoimidazole
Molecular formula	C14H11N3O2
IUPAC name	2-(4-methylphenyl)-6-nitro-1H-benzimidazole
Molecular weight	253.261
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	3.8
Synonyms	SMR000279525 CHEMBL1446966 NCI60_019802 ZINC5504055 1H-benzimidazole, 2-(4-methylphenyl)-5-nitro- AC1Q21C3 EU-0033453 Oprea1_576997 SCHEMBL14103639 2-(4-methylphenyl)-6-nitro-1H-benzimidazole BDBM49811 MLS000717957 SR-01000389451 6-nitro-2-(p-tolyl)-1H-benzimidazole cid_376349 NSC-657181 Oprea1_671510 2-(4-Methylphenyl)-5-nitro-1H-benzoimidazole AKOS000297244 HMS2667I07 SCHEMBL17898263 5-Nitro-2-(4-methylphenyl)benzimidazole MolPort-001-914-006 SR-01000389451-1 1571-90-0 AC1L8CFN CTK6B8151 NSC657181 SCHEMBL13856173 2-(4-methylphenyl)-5-nitrobenzimidazole BAS 00082638 MCULE-7686884703 [ Show all ]
Inchi Key	AAMPIRQLXWIYCV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H11N3O2/c1-9-2-4-10(5-3-9)14-15-12-7-6-11(17(18)19)8-13(12)16-14/h2-8H,1H3,(H,15,16)
PubChem CID	376349
ChEMBL	CHEMBL1446966
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	10000.0 nM	PubChem BioAssay data set	ChEMBL

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