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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 7
Species	Homo sapiens (Human)
Gene	HTR7
Synonym	5-HT-7 Serotonin receptor 7 5-HT-X 5-HT1Y 5-HT7 GPRFO 5-HT7 receptor 5-HTx 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled [ Show all ]
Disease	Sleep disorders Schizophrenia Major depressive disorder
Length	479
Amino acid sequence	MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
UniProt	P34969
Protein Data Bank	N/A
GPCR-HGmod model	P34969
3D structure model	This predicted structure model is from GPCR-EXP P34969.
BioLiP	N/A
Therapeutic Target Database	T79062
ChEMBL	CHEMBL3155
IUPHAR	12
DrugBank	BE0000650, BE0004862

Ligand

Name	CHEMBL263700
Molecular formula	C19H20N2O2
IUPAC name	[3-[2-(dimethylamino)ethyl]-5-hydroxyindol-1-yl]-phenylmethanone
Molecular weight	308.381
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	3.5
Synonyms	N,N-Dimethyl-1-benzoyl-5-hydroxy-1H-indole-3-ethanamine [3-(2-Dimethylamino-ethyl)-5-hydroxy-1H-indol-1-yl]phenylmethanone SCHEMBL7443507 [3-(2-Dimethylamino-ethyl)-5-hydroxy-indol-1-yl]-phenyl-methanone UJELDYRUBKQNKE-UHFFFAOYSA-N BDBM50106252 [ Show all ]
Inchi Key	UJELDYRUBKQNKE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H20N2O2/c1-20(2)11-10-15-13-21(18-9-8-16(22)12-17(15)18)19(23)14-6-4-3-5-7-14/h3-9,12-13,22H,10-11H2,1-2H3
PubChem CID	9796627
ChEMBL	CHEMBL263700
IUPHAR	N/A
BindingDB	50106252
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1600.0 nM	PMID11689074	BindingDB,ChEMBL

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