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GPCR

Name5-hydroxytryptamine receptor 2A
SpeciesRattus norvegicus (Rat)
GeneHtr2a
Synonymserotonin 5HT-2 receptor
5Ht-2
'D' receptor
5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
5-HT2A receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length471
Amino acid sequenceMEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
UniProtP14842
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL322
IUPHAR6
DrugBankN/A

Ligand

NameBDBM50265778
Molecular formulaC26H30N4O2
IUPAC nameN-[4-(5-methoxy-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl)butyl]-1,4-dihydroisoquinoline-3-carboxamide
Molecular weight430.552
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP3.1
SynonymsN-[4-(1,2,3,4-Tetrahydro-5-methoxy--carbolin-2-yl)butyl]isoquinoline-3-carboxamide
Inchi KeyBURMBJGIJZXZNP-UHFFFAOYSA-N
Inchi IDInChI=1S/C26H30N4O2/c1-32-24-10-6-9-21-25(24)20-11-14-30(17-23(20)29-21)13-5-4-12-27-26(31)22-15-18-7-2-3-8-19(18)16-28-22/h2-3,6-10,29H,4-5,11-17H2,1H3,(H,27,31)
PubChem CID91935078
ChEMBLN/A
IUPHARN/A
BindingDB50265778
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki149.0 nMPMID19072656BindingDB

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