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Name | G-protein coupled receptor 4 |
---|---|
Species | Homo sapiens (Human) |
Gene | GPR4 |
Synonym | G-protein coupled receptor 19 GPR19 GPR4 |
Disease | N/A |
Length | 362 |
Amino acid sequence | MGNHTWEGCHVDSRVDHLFPPSLYIFVIGVGLPTNCLALWAAYRQVQQRNELGVYLMNLSIADLLYICTLPLWVDYFLHHDNWIHGPGSCKLFGFIFYTNIYISIAFLCCISVDRYLAVAHPLRFARLRRVKTAVAVSSVVWATELGANSAPLFHDELFRDRYNHTFCFEKFPMEGWVAWMNLYRVFVGFLFPWALMLLSYRGILRAVRGSVSTERQEKAKIKRLALSLIAIVLVCFAPYHVLLLSRSAIYLGRPWDCGFEERVFSAYHSSLAFTSLNCVADPILYCLVNEGARSDVAKALHNLLRFLASDKPQEMANASLTLETPLTSKRNSTAKAMTGSWAATPPSQGDQVQLKMLPPAQ |
UniProt | P46093 |
Protein Data Bank | N/A |
GPCR-HGmod model | P46093 |
3D structure model | This predicted structure model is from GPCR-EXP P46093. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3638324 |
IUPHAR | N/A |
DrugBank | N/A |
Name | GPR4 antagonist 1 |
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Molecular formula | C27H37N5 |
IUPAC name | 2-ethyl-5,7-dimethyl-3-[[4-[(E)-3-(4-propan-2-ylpiperazin-1-yl)prop-1-enyl]phenyl]methyl]imidazo[4,5-b]pyridine |
Molecular weight | 431.628 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 0 |
XlogP | 5.0 |
Synonyms | AKOS032954216 SCHEMBL4326230 CHEMBL3675746 1197879-16-5 GPR4 Antagonist C39c [ Show all ] |
Inchi Key | UAMIBPKKKLTAKG-BQYQJAHWSA-N |
Inchi ID | InChI=1S/C27H37N5/c1-6-25-29-26-21(4)18-22(5)28-27(26)32(25)19-24-11-9-23(10-12-24)8-7-13-30-14-16-31(17-15-30)20(2)3/h7-12,18,20H,6,13-17,19H2,1-5H3/b8-7+ |
PubChem CID | 57970302 |
ChEMBL | CHEMBL3675746 |
IUPHAR | N/A |
BindingDB | 123515 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 55.0 nM | , None | BindingDB,ChEMBL |
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