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GLASS

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GPCR

Name	5-hydroxytryptamine receptor 1B
Species	Homo sapiens (Human)
Gene	HTR1B
Synonym	5-HT1B receptor 5-HT-1B 5-HT-1D-beta 5-HT1B Serotonin 1D beta receptor HTR1D2 5-HT1B serotonin receptor 5-HT1DB 5-HT1Dbeta 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled serotonin receptor 1B S12 [ Show all ]
Disease	Chronic schizophrenics Major depressive disorder Migraine headaches Mood disorder Psychotic disorders Anxiety disorder [ Show all ]
Length	390
Amino acid sequence	MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS
UniProt	P28222
Protein Data Bank	4iar, 6g79, 5v54
GPCR-HGmod model	P28222
3D structure model	This structure is from PDB ID 4iar.
BioLiP	BL0239857, BL0403524,BL0403525, BL0417722
Therapeutic Target Database	T07806
ChEMBL	CHEMBL1898
IUPHAR	2
DrugBank	BE0000797

Ligand

Name	memantine
Molecular formula	C12H21N
IUPAC name	3,5-dimethyladamantan-1-amine
Molecular weight	179.307
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	3.3
Synonyms	KBio2_006223 1-amino-3,5-dimethyladamantan Memantin 3,5-dimethyladamantan-1-amine Memantine [INN:BAN] AB00053600_14 NCGC00015705-07 alzantin Prestwick2_000978 Biomol-NT_000209 SPBio_001456 CBMicro_020348 STK520682 D08174 W8O17SJF3T DSSTox_CID_25174 FT-0649142 HSDB 7327 KBioSS_001087 3,5-Dimethyl-1-adamantanamine 3,5-dimethyltricyclo[3.3.1.1~3,7~]decan-1-amine Memantinum [INN-Latin] AC1L1HB7 NCGC00024782-03 BB 0216388 SBB002574 BR-33967 Spectrum3_000923 CHEMBL807 Tox21_110199_1 DB01043 DTXSID5045174 KBio2_001087 1-amino-3,5-dimethyl adamantane LS-157051 3,5-Dimethyl-1-aminoadamantane hydrochlo Memantine (INN) AB00053600 NCGC00015705-04 AKOS016340748 Prestwick0_000978 BBV-39899297 SCHEMBL13213676 C13736 Spectrum_000607 D-145 Tricyclo[3.3.1.13,7]decan-1-amine, 3,5-dimethyl- DRG 0267 Exiba (TN) (3,5-Dimethyl-1-adamantyl)amine KBio3_001926 1-Amino-3,5-dimethyladamantane Memantina 3,5-dimethyladamantanylamine Memantine [INN] AB00053600_15 NCGC00015705-09 ANW-56451 Prestwick3_000978 BPBio1_001117 SPBio_002926 CCG-204092 TC-145196 D145 ZERO/006024 DSSTox_GSID_45174 GTPL4253 IDI1_000068 1,3-Dimethyl-5-adamantanamine KS-000024QT 3,5-Dimethyl-1-adamantylamine Memantine (extended release) 41100-52-1 (Hydrochloride) MolPort-002-041-858 AKOS000113995 NINDS_000068 BB0216388 SBI-0020417.P004 BSPBio_001015 Spectrum4_001022 CTK6B3298 Tricyclo(3.3.1.1(3,7))decan-1-amine, 3,5-dimethyl- DivK1c_000068 Ebixa KBio2_003655 1-amino-3,5-dimethyl-adamantane MCULE-3726352671 3,5-Dimethyl-adamantan-1-ylamine Memantine ER AB00053600-13 NCGC00015705-05 ALBB-013872 Prestwick1_000978 BDBM50062599 SCHEMBL2688 CAS-19982-08-2 ST057652 D01JEU UNII-W8O17SJF3T DS-3152 FCH1198345 (3,5-Dimethyl-1-adamantyl)amine hydrochloride KBioGR_001543 19982-08-2 Memantina [INN-Spanish] 3,5-Dimethyltricyclo(3.3.1.1(3,7))decan-1-amine Memantinum AB0212255 NCGC00024782-02 AZ0001-0553 S-1686 BPBio1_001270 Spectrum2_001408 CHEBI:64312 Tox21_110199 ZX-AN012621 DSSTox_RID_80723 HMS500D10 KBio1_000068 1,3-Dimethyl-5-aminoadamantane Lopac0_000861 3,5-Dimethyl-1-aminoadamantane Memantine (extended release), Forest 51052-62-1 NCGC00015705-03 AKOS015953276 Oprea1_480562 BBL000737 SC-45525 BUGYDGFZZOZRHP-UHFFFAOYSA-N Spectrum5_001355 D 145 Tricyclo(3.3.1.13,7)decan-1-amine, 3,5-dimethyl- DMAA [Antiparkinson Agent] EU-0053634 [ Show all ]
Inchi Key	BUGYDGFZZOZRHP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3
PubChem CID	4054
ChEMBL	N/A
IUPHAR	N/A
BindingDB	N/A
DrugBank	DB01043
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	http://pdsp.med.unc.edu/pdsp.php	PDSP

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