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GPCR

Name	D(2) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD2
Synonym	dopamine receptor 2 Dopamine D2 receptor D2R D2A and D_2B D2(415) and D₂₍₄₄₄₎ D2 receptor [ Show all ]
Disease	Substance dependence Major depressive disorder Maintain blood pressure in hypotensive states Insomnia Inflammatory disease Inflammatory bowel disease Idiopathic thrombocytopenic purpura Hypertension; Angina pectoris Hypertension Hyperprolactinemia Huntington's disease Glaucoma Gastrointestinal problems Malignant phaeochromocytoma; Benign prostatic hypertrophy; Malignant essential hypertension Migraine headaches Nasal congestion Sexual dysfunction Schizophrenia; Schizoaffective disorders Schizophrenia; Bipolar disorder Schizophrenia Psychotic disorders Psychosis Postpartum haemorrhage Peripheral vasoconstriction; Pulmonary hypertension Parkinson's disease Pain; Inflammatory diseases Ophthalmic disease Non-small cell lung cancer Nausea; Vomiting Fibrosis False perceptions; Bipolar disorder Emesis Chronic obstructive pulmonary disease Cerebrovascular ischaemia Cardiotonic Cardiac failure Bacterial infections Breast cancer Bipolar disorder; Schizophrenia Bipolar disorder Corneal vascularity; Hyperaemia; Itching Asthma; Bronchitis Anxiety disorder Carcinoid syndrome; Acromegaly Advanced stage Parkinson's disease Dermal necrosis Depressive fatigue Alcohol use disorders Allergy Alzheimer disease Hypotension [ Show all ]
Length	443
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
UniProt	P14416
Protein Data Bank	6cm4, 6c38
GPCR-HGmod model	P14416
3D structure model	This structure is from PDB ID 6cm4.
BioLiP	BL0408379, BL0403379
Therapeutic Target Database	T67162
ChEMBL	CHEMBL217
IUPHAR	215
DrugBank	BE0000756

Ligand

Name	aspirin
Molecular formula	C9H8O4
IUPAC name	2-acetyloxybenzoic acid
Molecular weight	180.159
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	1.2
Synonyms	UNII-R16CO5Y76E SCHEMBL1353 DB00945 Acetylsalicylic acid, 99% NCGC00015067-08 Aspirina 03 1777-EP2314590A1 SP 189 DTXSID5020108 AcetylsalicylicAcid NCGC00090977-02 Azetylsalizylsaeure 2-(Acetyloxy)-benzoic acid Spira-Dine Ecolen Acetysalicylic acid NCGC00260723-01 Bayer Children's Aspirin 2-acetyloxybenzoic acid STL137674 Entericin Acido O-acetil-benzoico [Italian] NSC-755899 BCP21790 4-10-00-00138 (Beilstein Handbook Reference) F2191-0068 AIN O-accetylsalicylic acid BIDD:GT0118 6474-EP2298764A1 KBio2_004839 HMS2090G03 Asacard Persistin CCG-39490 A.S.A. empirin KBioSS_002272 HSDB 652 Pravigard PAC (Salt/Mix) Clariprin Acenterine Lopac-A-5376 KB-47125 11126-37-7 Ronal component of Darvon with A.S.A (Salt/Mix) Acetonyl MFCD00002430 Aspergum 1777-EP2280008A2 Salicylic acid, acetate Contrheuma retard acetyl-salicylic acid MolPort-000-871-622 Aspirin USP (3080) 1777-EP2298768A1 Tox21_202117 XAXA 1777-EP2305260A1 Solprin DivK1c_000555 Acetylsalicylic acid, analytical standard NCGC00015067-11 Asprin 1777-EP2371811A2 Spectrum2_001899 Durlaza ER Acetylsalicylsaure (GERMAN) NCGC00090977-05 BAY-1019036 2-acetoxy benzoic acid SR-01000075668-4 Empirin Acide acetylsalicylique (FRENCH) NINDS_000555 Bayer Enteric 81 mg Adult Low Strength 2087491-38-9 Tasprin Enterosarine Acisal NSC755899 Benzoic acid, 2-(acetyloxy)- 6474-EP2272832A1 Globoid Aloxiprimum O-Acetylsalicylic acid Bufferin 8-hour Bayer KBio3_002149 HMS3260G17 Asatard Pirseal CHEBI:15365 AB00051918_10 Kyselina 2-acetoxybenzoova IDI1_000555 R16CO5Y76E Colsprin Acetard LS-143 1777-EP2269989A1 s3017 component of Robaxisal Acetosalic acid Miniasal 1777-EP2281818A1 Salycylacetylsalicylic acid D00109 Acetylsalicyclic acid NCGC00015067-03 Aspirin [USP:BAN:JAN] Triaminicin ZINC53 Acetylsalicylic Acid 1.0 mg/ml in Acetonitrile NCGC00015067-06 Aspirin, United States Pharmacopeia (USP) Reference Standard 1777-EP2308510A1 Solupsan DSSTox_GSID_20108 Acetylsalicylic acid, European Pharmacopoeia (EP) Reference Standard NCGC00015067-14 Aspropharm 1oxr Spectrum5_000740 EC 200-064-1 Acetyonyl NCGC00254034-01 Bayer Aspirin 8 Hour 2-Acetoxybenzoic acid St. Joseph Aspirin for Adults Endosprin Acido acetilsalicilico [Italian] NSC-27223 BBL005469 24189-EP2314590A1 Tox21_110076 EU-0100038 Adiro o-(Acetyloxy)benzoate Bialpirina 6474-EP2277875A2 KBio2_002271 Helicon Arthritis Pain Formula Maximum Strength (Salt/Mix) Percodan (Salt/Mix) Cardioaspirina A.S.A KBioGR_002271 HMS3715P19 Ascriptin (Salt/Mix) Polopiryna cid_2244 AC1L1D8U Kyselina acetylsalicylova [Czech] Istopirin Rhodine component of Coricidin Acetilum acidulatum Measurin Aspalon (JAN) 1777-EP2275420A1 Saletin component of Zactirin acetyl salicyclic acid MLS001336045 Aspirin (JP17/USP) 1777-EP2298764A1 SC-18564 D41527A7-A9EB-472D-A7FC-312821130549 UNM-0000306102 SMR000059138 Decaten Acetylsalicylic acid, >=99% NCGC00015067-09 Aspirine 1777-EP2314593A1 SPBio_001838 Duramax Acetylsalicylsaeure NCGC00090977-03 Azetylsalizylsaure 2-(acetyloxy)benzoate SR-01000075668 Ecotrin acide 2-(acetyloxy)benzoique NCI60_002222 Bayer Enteric 325 mg Regular Strength 2-Acetylsalicyclic acid Supac Enterophen Acidum acetylsalicylicum NSC27223 BDBM22360 50-78-2 FT-0655181 AJ-07843 o-Acetoxybenzoate BRN 0779271 6474-EP2298765A1 KBio2_006861 HMS2091K13 Asagran Pharmacin CCRIS 3243 AB00051918-08 KS-00000ULP HY-14654 Premaspin cMAP_000006 Acesal Lopac0_000038 170197-EP2275413A1 RTX-012224 component of Midol Acetophen Micrainin (Salt/Mix) Aspir-Mox 1777-EP2281563A1 Salicylic acid, acetyl- CS-2001 Acetylin NCGC00015067-01 Aspirin USP-26 1777-EP2298776A1 Tox21_300146 Yasta Aspirin, British Pharmacopoeia (BP) Reference Standard 1777-EP2305640A2 Solprin acid Dolean pH 8 ACETYLSALICYLIC ACID, ASPIRIN NCGC00015067-12 Aspro 186947-EP2270113A1 Spectrum3_001295 Easprin Acetylsalicylsaure [German] NCGC00090977-06 Bay-e-4465 2-Acetoxybenzenecarboxylic acid SR-01000075668-6 Empirin with Codeine Acide acetylsalicylique [French] Novid Bayer Extra Strength Aspirin for Migraine Pain 2349-94-2 Temperal Entrophen ACMC-209kpz Nu-seals Benzoicacid, 2-(acetyloxy)- 6474-EP2275420A1 KBio1_000555 GTPL4139 AN-24382 O-Acetylsalicylic acid; Aspirin C01405 98201-60-6 KBio3_002751 HMS3372N15 Ascoden-30 PL-2200 AB1003266 Kyselina 2-acetoxybenzoova [Czech] Idragin Rheumin tabletten component of Ascodeen-30 Aceticyl Magnecyl 1777-EP2269990A1 Salacetin component of St. Joseph Cold Tablets Acetosalin MLS001055329 Aspirin (Acetyl Salicylic Acid), Pharmaceutical Secondary Standard; Certified Reference Material 1777-EP2292227A2 SBB015069 D0GY5Z Acetylsalicylate NCGC00015067-04 Triple-sal ZORprin Acetylsalicylic acid for peak identification, European Pharmacopoeia (EP) Reference Standard NCGC00015067-07 Aspirin,(S) 1777-EP2311453A1 Soma Compound (Salt/Mix) DSSTox_RID_75372 Acetylsalicylic acid, Vetec(TM) reagent grade, >=99% NCGC00090977-01 Asteric 2-(AcetYl-Oxy)Benzoic Acid Spectrum_001245 ECM Acetysal NCGC00259666-01 Bayer Buffered 2-Acetoxybenzoic acid; O-Acetylsalicylic acid; ASA; Aspirin ST075414 Endydol Acido O-acetil-benzoico NSC-406186 BC221833 26914-13-6 Extren AI3-02956 o-(Acetyloxy)benzoic acid Bialpirinia 6474-EP2298757A2 KBio2_004293 HMS1920E13 ASA Percodan Demi (Salt/Mix) CAS-50-78-2 A.S.A. KBioSS_001725 HMS501L17 Aspalon Pravigard Claradin AC1Q1LA0 Levius Kapsazal 11126-35-5 Rhonal component of Darvon with A.S.A Acetisal Medisyl Aspec 1777-EP2277865A1 Salicylic acid acetate component of Zactirin (Salt/Mix) acetyl salicylic acid MLS001336046 Aspirin USP (2080B) 1777-EP2298765A1 SC-61857 Tox21_110076_1 WLN: QVR BOV1 1777-EP2305219A1 Solfrin Delgesic Acetylsalicylic acid, >=99.0% NCGC00015067-10 AspirinTest2 1777-EP2316459A1 SPECTRUM1500130 Durlaza Acetylsalicylsaure NCGC00090977-04 Bay E4465 2-(Acetyloxy)benzoic acid SR-01000075668-1 EINECS 200-064-1 Acide acetylsalicylique Neuronika Bayer Enteric 500 mg Arthritis Strength 2-Carboxyphenyl acetate SW199665-2 Enterosarein Acimetten NSC406186 Benaspir 6474-EP1441224A2 Globentyl AKOS000118884 o-Acetoxybenzoic acid BSYNRYMUTXBXSQ-UHFFFAOYSA-N 6474-EP2314585A1 KBio2_007407 HMS2233L18 Asaphen Pharmakon1600-01500130 Cemirit AB00051918_09 KSC269M6D I14-7505 PubChem20190 Colfarit Acesan LP00038 170197-EP2287156A1 S-211 component of Persistin Acetosal Micristin Aspirdrops 1777-EP2281815A1 Salospir CTK1G9661 Acetylsal NCGC00015067-02 Aspirin [BAN:JAN] Tox21_500038 Z234893989 NCGC00015067-05 Aspirin, meets USP testing specifications 1777-EP2305652A2 Solpyron DSSTox_CID_108 Acetylsalicylic acid, BioReagent, plant cell culture tested, >=99.0% NCGC00015067-13 Aspro Clear 186947-EP2272935A1 Spectrum4_000099 Easprin (TN) Acetylsalycilic acid NCGC00090977-07 Bayer 2-Acetoxybenzoate St. Joseph Empirin with Codeine (Salt/Mix) Acido acetilsalicilico NSC 27223 Bayer Plus 24189-EP2295409A1 Toldex Epitope ID:114151 Acylpyrin Nu-seals aspirin Bi-prin 6474-EP2277861A1 KBio2_001725 H740 ANW-31125 o-Carboxyphenyl acetate Cardioaspirin A 5376 KBioGR_000398 HMS3656N14 Ascolong Polopirin CHEMBL25 AC 5230 Kyselina acetylsalicylova InChI=1/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12 (non-d)Acetylsalicylic Acid-d3 Rheumintabletten component of Ascodeen-30 (Salt/Mix) Acetilsalicilico MCULE-3199019536 1777-EP2272825A2 Salcetogen component of Synirin Acetoxybenzoic acid MLS001066332 aspirin (acetylsalicylic acid) 1777-EP2295055A2 SBI-0050027.P004 D0XB8R ACETYLSALICYLIC ACID [ Show all ]
Inchi Key	BSYNRYMUTXBXSQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
PubChem CID	2244
ChEMBL	CHEMBL25
IUPHAR	N/A
BindingDB	N/A
DrugBank	DB00945
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	http://pdsp.med.unc.edu/pdsp.php	PDSP

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