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GPCR

Name	D(2) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD2
Synonym	dopamine receptor 2 Dopamine D2 receptor D2R D2A and D_2B D2(415) and D₂₍₄₄₄₎ D2 receptor [ Show all ]
Disease	Substance dependence Major depressive disorder Maintain blood pressure in hypotensive states Insomnia Inflammatory disease Inflammatory bowel disease Idiopathic thrombocytopenic purpura Hypertension; Angina pectoris Hypertension Hyperprolactinemia Huntington's disease Glaucoma Gastrointestinal problems Malignant phaeochromocytoma; Benign prostatic hypertrophy; Malignant essential hypertension Migraine headaches Nasal congestion Sexual dysfunction Schizophrenia; Schizoaffective disorders Schizophrenia; Bipolar disorder Schizophrenia Psychotic disorders Psychosis Postpartum haemorrhage Peripheral vasoconstriction; Pulmonary hypertension Parkinson's disease Pain; Inflammatory diseases Ophthalmic disease Non-small cell lung cancer Nausea; Vomiting Fibrosis False perceptions; Bipolar disorder Emesis Chronic obstructive pulmonary disease Cerebrovascular ischaemia Cardiotonic Cardiac failure Bacterial infections Breast cancer Bipolar disorder; Schizophrenia Bipolar disorder Corneal vascularity; Hyperaemia; Itching Asthma; Bronchitis Anxiety disorder Carcinoid syndrome; Acromegaly Advanced stage Parkinson's disease Dermal necrosis Depressive fatigue Alcohol use disorders Allergy Alzheimer disease Hypotension [ Show all ]
Length	443
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
UniProt	P14416
Protein Data Bank	6cm4, 6c38
GPCR-HGmod model	P14416
3D structure model	This structure is from PDB ID 6cm4.
BioLiP	BL0408379, BL0403379
Therapeutic Target Database	T67162
ChEMBL	CHEMBL217
IUPHAR	215
DrugBank	BE0000756

Ligand

Name	aspirin
Molecular formula	C9H8O4
IUPAC name	2-acetyloxybenzoic acid
Molecular weight	180.159
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	1.2
Synonyms	Easprin (TN) Bayer Empirin with Codeine (Salt/Mix) Bayer Plus Epitope ID:114151 Bi-prin H740 Cardioaspirin HMS3656N14 CHEMBL25 InChI=1/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12 component of Ascodeen-30 (Salt/Mix) UNII-R16CO5Y76E component of Synirin aspirin (acetylsalicylic acid) D0XB8R Aspirin, meets USP testing specifications DSSTox_CID_108 Aspro Clear AB00051918-08 Salicylic acid, acetate MolPort-000-871-622 Acesal SCHEMBL1353 170197-EP2275413A1 NCGC00015067-08 Acetophen SP 189 1777-EP2281563A1 NCGC00090977-02 Acetylin Spira-Dine 1777-EP2298776A1 NCGC00260723-01 Acetylsalicylic acid, >=99% STL137674 1777-EP2314593A1 NSC-755899 Acetylsalicylsaeure 2-(acetyloxy)benzoate O-accetylsalicylic acid acide 2-(acetyloxy)benzoique KBio2_004839 2-Acetylsalicyclic acid Persistin Acidum acetylsalicylicum KBioSS_002272 50-78-2 Pravigard PAC (Salt/Mix) AJ-07843 Lopac-A-5376 6474-EP2298765A1 Ronal Asagran MFCD00002430 Azetylsalizylsaeure Ecolen Bayer Children's Aspirin Entericin BCP21790 F2191-0068 BIDD:GT0118 HMS2090G03 CCG-39490 HSDB 652 Clariprin Tox21_202117 KB-47125 component of Darvon with A.S.A (Salt/Mix) XAXA Aspergum Contrheuma retard Aspirin USP (3080) DB00945 Aspirina 03 DTXSID5020108 Ascoden-30 Miniasal AB1003266 Salycylacetylsalicylic acid NCGC00015067-03 Aceticyl Solprin 1777-EP2269990A1 NCGC00015067-11 Acetosalin Spectrum2_001899 1777-EP2292227A2 NCGC00090977-05 Acetylsalicylate SR-01000075668-4 1777-EP2305640A2 NINDS_000555 ACETYLSALICYLIC ACID, ASPIRIN Tasprin 186947-EP2270113A1 NSC755899 Acetylsalicylsaure [German] 2-Acetoxybenzenecarboxylic acid O-Acetylsalicylic acid Acide acetylsalicylique [French] KBio3_002149 2349-94-2 Pirseal ACMC-209kpz Kyselina 2-acetoxybenzoova 6474-EP2275420A1 R16CO5Y76E AN-24382 LS-143 98201-60-6 s3017 BAY-1019036 Empirin Bayer Enteric 81 mg Adult Low Strength Enterosarine Benzoic acid, 2-(acetyloxy)- Globoid Bufferin HMS3260G17 CHEBI:15365 IDI1_000555 Colsprin Triaminicin component of Robaxisal ZINC53 D00109 Aspirin [USP:BAN:JAN] DivK1c_000555 Asprin Durlaza ER Saletin Aspalon MLS001336045 AC1Q1LA0 SC-18564 11126-35-5 NCGC00015067-06 Acetisal Solupsan 1777-EP2277865A1 NCGC00015067-14 acetyl salicylic acid Spectrum5_000740 1777-EP2298765A1 NCGC00254034-01 Acetylsalicylic acid for peak identification, European Pharmacopoeia (EP) Reference Standard St. Joseph Aspirin for Adults 1777-EP2311453A1 NSC-27223 Acetylsalicylic acid, Vetec(TM) reagent grade, >=99% Tox21_110076 2-(AcetYl-Oxy)Benzoic Acid o-(Acetyloxy)benzoate Acetysal KBio2_002271 2-Acetoxybenzoic acid; O-Acetylsalicylic acid; ASA; Aspirin Percodan (Salt/Mix) Acido O-acetil-benzoico KBioGR_002271 26914-13-6 Polopiryna AI3-02956 Kyselina acetylsalicylova [Czech] 6474-EP2298757A2 Rhodine ASA Measurin A.S.A. EC 200-064-1 Bayer Aspirin 8 Hour Endosprin BBL005469 EU-0100038 Bialpirina Helicon Cardioaspirina HMS3715P19 cid_2244 Istopirin component of Coricidin UNM-0000306102 Aspalon (JAN) component of Zactirin Aspirin (JP17/USP) D41527A7-A9EB-472D-A7FC-312821130549 Aspirin, United States Pharmacopeia (USP) Reference Standard DSSTox_GSID_20108 Aspropharm AB00051918_09 Salicylic acid, acetyl- NCGC00015067-01 Acesan SMR000059138 170197-EP2287156A1 NCGC00015067-09 Acetosal SPBio_001838 1777-EP2281815A1 NCGC00090977-03 Acetylsal SR-01000075668 1777-EP2305219A1 NCI60_002222 Acetylsalicylic acid, >=99.0% Supac 1777-EP2316459A1 NSC27223 Acetylsalicylsaure 2-(Acetyloxy)benzoic acid o-Acetoxybenzoate Acide acetylsalicylique KBio2_006861 2-Carboxyphenyl acetate Pharmacin Acimetten KS-00000ULP 6474-EP1441224A2 Premaspin AKOS000118884 Lopac0_000038 6474-EP2314585A1 RTX-012224 Asaphen Micrainin (Salt/Mix) Azetylsalizylsaure Ecotrin Bayer Enteric 325 mg Regular Strength Enterophen BDBM22360 FT-0655181 BRN 0779271 HMS2091K13 CCRIS 3243 HY-14654 cMAP_000006 Tox21_300146 component of Midol Yasta Aspir-Mox CS-2001 Aspirin USP-26 Decaten Aspirine Duramax Ascolong MLS001055329 AC 5230 SBB015069 (non-d)Acetylsalicylic Acid-d3 NCGC00015067-04 Acetilsalicilico Solprin acid 1777-EP2272825A2 NCGC00015067-12 Acetoxybenzoic acid Spectrum3_001295 1777-EP2295055A2 NCGC00090977-06 ACETYLSALICYLIC ACID SR-01000075668-6 1777-EP2305652A2 Novid Acetylsalicylic acid, BioReagent, plant cell culture tested, >=99.0% Temperal 186947-EP2272935A1 Nu-seals Acetylsalycilic acid KBio1_000555 2-Acetoxybenzoate O-Acetylsalicylic acid; Aspirin Acido acetilsalicilico KBio3_002751 24189-EP2295409A1 PL-2200 Acylpyrin Kyselina 2-acetoxybenzoova [Czech] 6474-EP2277861A1 Rheumin tabletten ANW-31125 Magnecyl A 5376 Salacetin Easprin Bay-e-4465 Empirin with Codeine Bayer Extra Strength Aspirin for Migraine Pain Entrophen Benzoicacid, 2-(acetyloxy)- GTPL4139 C01405 HMS3372N15 Idragin component of Ascodeen-30 Triple-sal component of St. Joseph Cold Tablets ZORprin Aspirin (Acetyl Salicylic Acid), Pharmaceutical Secondary Standard; Certified Reference Material D0GY5Z Aspirin, British Pharmacopoeia (BP) Reference Standard Dolean pH 8 Aspro A.S.A. empirin Salicylic acid acetate MLS001336046 Acenterine SC-61857 11126-37-7 NCGC00015067-07 Acetonyl Soma Compound (Salt/Mix) 1777-EP2280008A2 NCGC00090977-01 acetyl-salicylic acid Spectrum_001245 1777-EP2298768A1 NCGC00259666-01 Acetylsalicylic acid, 99% ST075414 1777-EP2314590A1 NSC-406186 AcetylsalicylicAcid 2-(Acetyloxy)-benzoic acid o-(Acetyloxy)benzoic acid Acetysalicylic acid KBio2_004293 2-acetyloxybenzoic acid Percodan Demi (Salt/Mix) Acido O-acetil-benzoico [Italian] KBioSS_001725 4-10-00-00138 (Beilstein Handbook Reference) Pravigard AIN Levius 6474-EP2298764A1 Rhonal Asacard Medisyl ECM Bayer Buffered Endydol BC221833 Extren Bialpirinia HMS1920E13 CAS-50-78-2 HMS501L17 Claradin Tox21_110076_1 Kapsazal component of Darvon with A.S.A WLN: QVR BOV1 Aspec component of Zactirin (Salt/Mix) Aspirin USP (2080B) Aspirin,(S) DSSTox_RID_75372 Asteric AB00051918_10 Salospir NCGC00015067-02 Acetard Solfrin 1777-EP2269989A1 NCGC00015067-10 Acetosalic acid SPECTRUM1500130 1777-EP2281818A1 NCGC00090977-04 Acetylsalicyclic acid SR-01000075668-1 1777-EP2305260A1 Neuronika Acetylsalicylic acid, analytical standard SW199665-2 1777-EP2371811A2 NSC406186 Acetylsalicylsaure (GERMAN) 2-acetoxy benzoic acid o-Acetoxybenzoic acid Acide acetylsalicylique (FRENCH) KBio2_007407 2087491-38-9 Pharmakon1600-01500130 Acisal KSC269M6D 6474-EP2272832A1 PubChem20190 Aloxiprimum LP00038 8-hour Bayer S-211 Asatard Micristin Bay E4465 EINECS 200-064-1 Bayer Enteric 500 mg Arthritis Strength Enterosarein Benaspir Globentyl BSYNRYMUTXBXSQ-UHFFFAOYSA-N HMS2233L18 Cemirit I14-7505 Colfarit Tox21_500038 component of Persistin Z234893989 Aspirdrops CTK1G9661 Aspirin [BAN:JAN] Delgesic AspirinTest2 Durlaza Ascriptin (Salt/Mix) MLS001066332 AC1L1D8U SBI-0050027.P004 NCGC00015067-05 Acetilum acidulatum Solpyron 1777-EP2275420A1 NCGC00015067-13 acetyl salicyclic acid Spectrum4_000099 1777-EP2298764A1 NCGC00090977-07 Acetylsalicylic Acid 1.0 mg/ml in Acetonitrile St. Joseph 1777-EP2308510A1 NSC 27223 Acetylsalicylic acid, European Pharmacopoeia (EP) Reference Standard Toldex 1oxr Nu-seals aspirin Acetyonyl KBio2_001725 2-Acetoxybenzoic acid o-Carboxyphenyl acetate Acido acetilsalicilico [Italian] KBioGR_000398 24189-EP2314590A1 Polopirin Adiro Kyselina acetylsalicylova 6474-EP2277875A2 Rheumintabletten Arthritis Pain Formula Maximum Strength (Salt/Mix) MCULE-3199019536 A.S.A Salcetogen [ Show all ]
Inchi Key	BSYNRYMUTXBXSQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
PubChem CID	2244
ChEMBL	CHEMBL25
IUPHAR	N/A
BindingDB	N/A
DrugBank	DB00945
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	http://pdsp.med.unc.edu/pdsp.php	PDSP

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