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GLASS

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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	MLS000054201
Molecular formula	C15H13N3O4
IUPAC name	3-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]-4-oxophthalazine-1-carboxylic acid
Molecular weight	299.286
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	1.6
Synonyms	3-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]-4-oxophthalazine-1-carboxylic acid CHEMBL1342238 ZINC3256343 723318-19-2 HMS2279J15 3-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]-4-oxidanylidene-phthalazine-1-carboxylic acid BDBM97065 SMR000062091 3-[(3,5-dimethyl-4-isoxazolyl)methyl]-4-oxo-1-phthalazinecarboxylic acid cid_2372982 MCULE-9618149882 3-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]-4-oxo-3,4-dihydrophthalazine-1-carboxylic acid Z19629456 3-[(3,5-dimethylisoxazol-4-yl)methyl]-4-keto-phthalazine-1-carboxylic acid HMS1763P21 AC1M6GWF [ Show all ]
Inchi Key	BSEYOKRAYPUQKI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H13N3O4/c1-8-12(9(2)22-17-8)7-18-14(19)11-6-4-3-5-10(11)13(16-18)15(20)21/h3-6H,7H2,1-2H3,(H,20,21)
PubChem CID	2372982
ChEMBL	CHEMBL1342238
IUPHAR	N/A
BindingDB	97065
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<29906.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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