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GLASS

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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	MLS001125299
Molecular formula	C21H25N5O
IUPAC name	N-[1-(2,3-dimethylphenyl)-4,5,6,7-tetrahydroindazol-4-yl]-1-ethylpyrazole-4-carboxamide
Molecular weight	363.465
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	2.8
Synonyms	BDBM97151 N-[1-(2,3-dimethylphenyl)-4,5,6,7-tetrahydroindazol-4-yl]-1-ethyl-4-pyrazolecarboxamide cid_24817872 SMR000665943 MolPort-005-133-685 N-[1-(2,3-dimethylphenyl)-4,5,6,7-tetrahydroindazol-4-yl]-1-ethyl-pyrazole-4-carboxamide MCULE-5548232073 N-[1-(2,3-dimethylphenyl)-4,5,6,7-tetrahydro-1H-indazol-4-yl]-1-ethyl-1H-pyrazole-4-carboxamide CHEMBL1412747 N-[1-(2,3-dimethylphenyl)-4,5,6,7-tetrahydroindazol-4-yl]-1-ethylpyrazole-4-carboxamide [ Show all ]
Inchi Key	BQYFIAVBDDOJIP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H25N5O/c1-4-25-13-16(11-22-25)21(27)24-18-8-6-10-20-17(18)12-23-26(20)19-9-5-7-14(2)15(19)3/h5,7,9,11-13,18H,4,6,8,10H2,1-3H3,(H,24,27)
PubChem CID	24817872
ChEMBL	CHEMBL1412747
IUPHAR	N/A
BindingDB	97151
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	874.17 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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