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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Lysophosphatidic acid receptor 2
Species	Homo sapiens (Human)
Gene	LPAR2
Synonym	endothelial differentiation gene 4, lysophosphatidic acid G-protein-coupled receptor 4 LPA receptor 2 LPA-2 Edg4 Lysophosphatidic acid receptor Edg-4 Pbx4 pre-B-cell leukemia transcription factor 4 LPA2 receptor [ Show all ]
Disease	N/A
Length	351
Amino acid sequence	MVIMGQCYYNETIGFFYNNSGKELSSHWRPKDVVVVALGLTVSVLVLLTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWFLRQGLLDTSLTASVATLLAIAVERHRSVMAVQLHSRLPRGRVVMLIVGVWVAALGLGLLPAHSWHCLCALDRCSRMAPLLSRSYLAVWALSSLLVFLLMVAVYTRIFFYVRRRVQRMAEHVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGQVVLLLDGLGCESCNVLAVEKYFLLLAEANSLVNAAVYSCRDAEMRRTFRRLLCCACLRQSTRESVHYTSSAQGGASTRIMLPENGHPLMDSTL
UniProt	Q9HBW0
Protein Data Bank	N/A
GPCR-HGmod model	Q9HBW0
3D structure model	This predicted structure model is from GPCR-EXP Q9HBW0.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3724
IUPHAR	273
DrugBank	N/A

Ligand

Name	LPA2 antagonist 1
Molecular formula	C20H23Cl2N5O2S2
IUPAC name	N-[(2S)-1-[4-(3,4-dichlorophenyl)sulfonylpiperazin-1-yl]propan-2-yl]-7-methylthieno[3,2-d]pyrimidin-4-amine
Molecular weight	500.457
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	4.3
Synonyms	CS-3103 AKOS027314118 NCGC00390601-01 1017606-66-4 HY-18075 BCP11072 ZINC29126798 CHEMBL256470 BDBM50373826 [ Show all ]
Inchi Key	BPRNMVDTWIHULJ-AWEZNQCLSA-N
Inchi ID	InChI=1S/C20H23Cl2N5O2S2/c1-13-11-30-19-18(13)23-12-24-20(19)25-14(2)10-26-5-7-27(8-6-26)31(28,29)15-3-4-16(21)17(22)9-15/h3-4,9,11-12,14H,5-8,10H2,1-2H3,(H,23,24,25)/t14-/m0/s1
PubChem CID	24882686
ChEMBL	CHEMBL256470
IUPHAR	N/A
BindingDB	50373826
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	17.0 nM	PMID18178086	BindingDB,ChEMBL

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