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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
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GPCR

Name	Melanin-concentrating hormone receptor 2
Species	Homo sapiens (Human)
Gene	MCHR2
Synonym	G-protein coupled receptor 145 melanin-concentrating hormone receptor 2 MCHR-2 MCH2R MCH2 receptor MCH2 G protein-coupled receptor 145 MCH-2R MCH receptor 2 GPRv17 GPR145 MCH-R2 [ Show all ]
Disease	N/A
Length	340
Amino acid sequence	MNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF
UniProt	Q969V1
Protein Data Bank	N/A
GPCR-HGmod model	Q969V1
3D structure model	This predicted structure model is from GPCR-EXP Q969V1.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5038
IUPHAR	281
DrugBank	N/A

Ligand

Name	CHEMBL197429
Molecular formula	C28H28ClFN4O
IUPAC name	3-(3-chloro-4-fluorophenyl)-1-[[4-(3-cyanophenyl)phenyl]methyl]-1-(3-pyrrolidin-1-ylpropyl)urea
Molecular weight	491.007
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	5.6
Synonyms	BDBM50174828 3-(3-chloro-4-fluoro-phenyl)-1-(3''-cyano-biphenyl-4-ylmethyl)-1-(3-pyrrolidin-1-yl-propyl)-urea
Inchi Key	BPFHLARZSZGTAE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H28ClFN4O/c29-26-18-25(11-12-27(26)30)32-28(35)34(16-4-15-33-13-1-2-14-33)20-21-7-9-23(10-8-21)24-6-3-5-22(17-24)19-31/h3,5-12,17-18H,1-2,4,13-16,20H2,(H,32,35)
PubChem CID	44405421
ChEMBL	CHEMBL197429
IUPHAR	N/A
BindingDB	50174828
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<3000.0 nM	PMID16202583	BindingDB,ChEMBL

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