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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	G-protein coupled receptor 183
Species	Homo sapiens (Human)
Gene	GPR183
Synonym	EBI2 {ECO:0000303\|PubMed:8383238} lymphocyte-specific G protein-coupled receptor hEBI2 {ECO:0000303\|PubMed:22875855} GPR183 G protein-coupled receptor 183 EBI2 Epstein-Barr virus-induced G-protein coupled receptor 2 {ECO:0000303\|PubMed:8383238} EBV-induced G-protein coupled receptor 2 {ECO:0000303\|PubMed:8383238} EBV-induced G protein-coupled receptor 2 Epstein-Barr virus-induced gene 2 [ Show all ]
Disease	N/A
Length	361
Amino acid sequence	MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVNFMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERITCMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNGK
UniProt	P32249
Protein Data Bank	N/A
GPCR-HGmod model	P32249
3D structure model	This predicted structure model is from GPCR-EXP P32249.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3259470
IUPHAR	81
DrugBank	N/A

Ligand

Name	CHEMBL3262880
Molecular formula	C22H24N2O2
IUPAC name	(E)-3-(4-methylphenyl)-1-[4-(2-phenylacetyl)piperazin-1-yl]prop-2-en-1-one
Molecular weight	348.446
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	3.0
Synonyms	(E)-1-[4-(2-phenylacetyl)piperazin-1-yl]-3-(p-tolyl)prop-2-en-1-one BDBM50011722
Inchi Key	RDBPWRPWFJWWTN-VAWYXSNFSA-N
Inchi ID	InChI=1S/C22H24N2O2/c1-18-7-9-19(10-8-18)11-12-21(25)23-13-15-24(16-14-23)22(26)17-20-5-3-2-4-6-20/h2-12H,13-17H2,1H3/b12-11+
PubChem CID	86579902
ChEMBL	CHEMBL3262880
IUPHAR	N/A
BindingDB	50011722
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	19.0 nM	PMID24678947	BindingDB,ChEMBL
IC50	19.05 nM	PMID24678947	ChEMBL

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