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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(1B) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD5
Synonym	Gpcr1 DRD1L2 DRD1B dopamine receptor 5 Dopamine D5 receptor D5 receptor D1beta dopamine receptor D(5) dopamine receptor D(1B) dopamine receptor [ Show all ]
Disease	Solid tumours Schizophrenia
Length	477
Amino acid sequence	MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH
UniProt	P21918
Protein Data Bank	N/A
GPCR-HGmod model	P21918
3D structure model	This predicted structure model is from GPCR-EXP P21918.
BioLiP	N/A
Therapeutic Target Database	T46828
ChEMBL	CHEMBL1850
IUPHAR	218
DrugBank	BE0000145, BE0004889

Ligand

Name	CHEMBL1086790
Molecular formula	C19H18N2
IUPAC name	11,19-diazapentacyclo[12.6.1.02,11.03,8.018,21]henicosa-1(20),3,5,7,14(21),15,17-heptaene
Molecular weight	274.367
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	3.6
Synonyms	BDBM50313914 2,6,7,9,10,14b-Hexahydroindolo[3'',4'':3,4,5]azepino[2,1-a]-isoquinoline
Inchi Key	BOVIKQWJNPOZRM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H18N2/c1-2-6-15-13(4-1)8-10-21-11-9-14-5-3-7-17-18(14)16(12-20-17)19(15)21/h1-7,12,19-20H,8-11H2
PubChem CID	45379377
ChEMBL	CHEMBL1086790
IUPHAR	N/A
BindingDB	50313914
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1525.0 nM	PMID20180564	BindingDB,ChEMBL

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