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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Alpha-2C adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA2C
Synonym	alpha2-C4 Adra-2c ADRA2L2 ADRA2RL2 Adrenergic alpha2C- receptor class I adrenergic receptor alpha-2 adrenergic receptor subtype C4 alpha2C-adrenoceptor alpha-2C adrenergic receptor Alpha-2C adrenoceptor alpha-2C adrenoreceptor Alpha-2CAR [ Show all ]
Disease	Diabetic nephropathy; Fibromyalgia Hypertension Heart failure Glaucoma Alzheimer disease Asthma Erythema Contusion Depression Hypotension Male sexual disorders Neurological disease Obesity Ocular disease Allergic rhinitis Alcohol use disorders Ocular hypertension Poison intoxication Peptic ulcer Pain [ Show all ]
Length	462
Amino acid sequence	MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
UniProt	P18825
Protein Data Bank	N/A
GPCR-HGmod model	P18825
3D structure model	This predicted structure model is from GPCR-EXP P18825.
BioLiP	N/A
Therapeutic Target Database	T01777
ChEMBL	CHEMBL1916
IUPHAR	27
DrugBank	BE0004864, BE0000342, BE0004888

Ligand

Name	CHEMBL49137
Molecular formula	C12H13N5
IUPAC name	N-(4,5-dihydro-1H-imidazol-2-yl)-5-methylquinoxalin-6-amine
Molecular weight	227.271
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	0.3
Synonyms	SCHEMBL7028091 6-Quinoxalinamine, N-(4,5-dihydro-1H-imidazol-2-yl)-5-methyl- Imidazolidin-2-ylidene-(5-methyl-quinoxalin-6-yl)-amine AGN-191103 QZUXRMOPAGPTIY-UHFFFAOYSA-N 5-Methyl-6-(2-imidazolin-2-ylamino)quinoxaline 91147-45-4 L005026 BDBM50052880 SCHEMBL15195137 DTXSID00238427 AC1L4G4B N-(4,5-dihydro-1H-imidazol-2-yl)-5-methylquinoxalin-6-amine [ Show all ]
Inchi Key	QZUXRMOPAGPTIY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C12H13N5/c1-8-9(17-12-15-6-7-16-12)2-3-10-11(8)14-5-4-13-10/h2-5H,6-7H2,1H3,(H2,15,16,17)
PubChem CID	185076
ChEMBL	CHEMBL49137
IUPHAR	N/A
BindingDB	50052880
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	14.0 nM	N/A	BindingDB
EC50	14.13 nM	Bioorg. Med. Chem. Lett., (1995) 5:19:2255	ChEMBL
Intrinsic activity	1.0 -	Bioorg. Med. Chem. Lett., (1995) 5:19:2255	ChEMBL
Ki	27.0 nM	PMID8784451, PMID9016324	BindingDB,ChEMBL
Ki	28.0 nM	N/A	BindingDB
Ki	28.18 nM	Bioorg. Med. Chem. Lett., (1995) 5:19:2255	ChEMBL

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