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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	MLS000538535
Molecular formula	C15H15BrN2O2
IUPAC name	2-(4-bromo-2,5-dimethylphenoxy)-N-pyridin-4-ylacetamide
Molecular weight	335.201
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	3.1
Synonyms	2-(4-bromo-2,5-dimethylphenoxy)-N-4-pyridinylacetamide cid_1254286 AC1LNY23 2-(4-bromanyl-2,5-dimethyl-phenoxy)-N-pyridin-4-yl-ethanamide ZINC1065007 2-(4-bromo-2,5-dimethylphenoxy)-N-pyridin-4-ylacetamide HMS2441A21 AKOS022155538 MolPort-002-293-338 2-(4-bromo-2,5-dimethyl-phenoxy)-N-(4-pyridyl)acetamide CHEMBL1417355 MCULE-2246319198 BDBM97070 SMR000144572 [ Show all ]
Inchi Key	BOQVYTIYMDHSSL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H15BrN2O2/c1-10-8-14(11(2)7-13(10)16)20-9-15(19)18-12-3-5-17-6-4-12/h3-8H,9H2,1-2H3,(H,17,18,19)
PubChem CID	1254286
ChEMBL	CHEMBL1417355
IUPHAR	N/A
BindingDB	97070
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1401.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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