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GPCR

Name	Alpha-2A adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA2A
Synonym	alpha2D alpha2A-AR alpha2A-adrenoceptor alpha2A-adrenergic receptor alpha2A Alpha-2AAR Adra-2 Adra-2a ADRA2 ADRA2R Adrenergic alpha 2A receptor adrenergic receptor Alpha-2 adrenergic receptor subtype C10 Alpha-2A adrenoceptor Alpha-2A adrenoreceptor [ Show all ]
Disease	Attention deficit hyperactivity disorder Sexual dysfunction Pain
Length	450
Amino acid sequence	MGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
UniProt	P08913
Protein Data Bank	N/A
GPCR-HGmod model	P08913
3D structure model	This predicted structure model is from GPCR-EXP P08913.
BioLiP	N/A
Therapeutic Target Database	T11448
ChEMBL	CHEMBL1867
IUPHAR	25
DrugBank	BE0000289

Ligand

Name	Tramazoline
Molecular formula	C13H17N3
IUPAC name	N-(5,6,7,8-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazol-2-amine
Molecular weight	215.3
Hydrogen bond acceptor	1
Hydrogen bond donor	2
XlogP	2.0
Synonyms	PDSP2_001082 Tobispray Tramazolinum 2-(5,6,7, 8-tetrahydro-1-naphthylimino)-imidazolidine 3715-90-0 (mono-hydrochloride) BDBM50225288 Imidazolidin-2-ylidene-(5,6,7,8-tetrahydro-naphthalen-1-yl)-amine Rhynaspray Tramazolina ZINC1534528 (4,5-Dihydro-1H-imidazol-2-yl)-(5,6,7,8-tetrahydro-naphthalen-1-yl)-amine 2-(5,6,7,8-tetrahydronaphthalen-1-ylamino)-2-imidazoline AC1L1KJB D08624 Muconasal (TN) N-tetralin-5-yl-4,5-dihydro-1H-imidazol-2-amine SLE31693IV Tramazoline (INN) 1082-57-1 2-[(5,6,7,8-Tetrahydro-1-naphthyl)amino]-2-imidazoline BCP29020 DTXSID5046936 QQJLHRRUATVHED-UHFFFAOYSA-N Towk Tramazolinum [INN-Latin] 2-(5,6,7,8-tetrahydro-1-naphthylamino)-2-imidazoline 4,5-Dihydro-N-(5,6,7,8-tetrahydro-1-naphthalenyl)-1H-imidazol-2-amine CHEBI:134893 Imidazolidine,2-[(5,6,7,8-tetrahydronaphthal-1-yl]imino- SCHEMBL121944 Tramazolina [INN-Spanish] 2-imidazolin-2-yl(5,6,7,8-tetrahydro-1-naphthyl)amine AC1Q4UQJ D0ZT8D N-(5,6,7,8-Tetrahydro-1-naphthalenyl)-4,5-dihydro-1H-imidazol-2-amine # PDSP1_001098 STL483756 Tramazoline [INN:BAN] 1H-Imidazol-2-amine, 4,5-dihydro-N-(5,6,7,8-tetrahydro-1-naphthalenyl)- 2-[(5,6,7,8-tetrahydronaphthalen-1-yl)amino]-2-imidazoline BDBM50027056 EINECS 214-105-6 Rhinol TRAMAZOLIN UNII-SLE31693IV 2-(5,6,7,8-tetrahydro-1-naphthylimino)-imidazolidine CHEMBL32573 L000866 SCHEMBL8623881 082T571 2-imidazolin-2-yl(5,6,7,8-tetrahydro-1-naphthyl)amine tramazoline 2-(5,6,7,8-Tetrahydro-1-naphthylamino)-2-imidazoline 4,5-Dihydro- AN-48480 DB13064 N-(5,6,7,8-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazol-2-amine [ Show all ]
Inchi Key	QQJLHRRUATVHED-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H17N3/c1-2-6-11-10(4-1)5-3-7-12(11)16-13-14-8-9-15-13/h3,5,7H,1-2,4,6,8-9H2,(H2,14,15,16)
PubChem CID	5524
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50027056
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	31.62 nM	PMID9605427	BindingDB
Ki	31.6228 nM	PMID9605427	PDSP

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