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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Alpha-2C adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA2C
Synonym	alpha2-C4 Adra-2c ADRA2L2 ADRA2RL2 Adrenergic alpha2C- receptor class I adrenergic receptor alpha-2 adrenergic receptor subtype C4 alpha2C-adrenoceptor alpha-2C adrenergic receptor Alpha-2C adrenoceptor alpha-2C adrenoreceptor Alpha-2CAR [ Show all ]
Disease	Diabetic nephropathy; Fibromyalgia Hypertension Heart failure Glaucoma Alzheimer disease Asthma Erythema Contusion Depression Hypotension Male sexual disorders Neurological disease Obesity Ocular disease Allergic rhinitis Alcohol use disorders Ocular hypertension Poison intoxication Peptic ulcer Pain [ Show all ]
Length	462
Amino acid sequence	MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
UniProt	P18825
Protein Data Bank	N/A
GPCR-HGmod model	P18825
3D structure model	This predicted structure model is from GPCR-EXP P18825.
BioLiP	N/A
Therapeutic Target Database	T01777
ChEMBL	CHEMBL1916
IUPHAR	27
DrugBank	BE0004864, BE0000342, BE0004888

Ligand

Name	Tramazoline
Molecular formula	C13H17N3
IUPAC name	N-(5,6,7,8-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazol-2-amine
Molecular weight	215.3
Hydrogen bond acceptor	1
Hydrogen bond donor	2
XlogP	2.0
Synonyms	CHEMBL32573 L000866 Rhinol TRAMAZOLIN UNII-SLE31693IV 2-(5,6,7,8-tetrahydro-1-naphthylimino)-imidazolidine AN-48480 DB13064 N-(5,6,7,8-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazol-2-amine SCHEMBL8623881 082T571 2-imidazolin-2-yl(5,6,7,8-tetrahydro-1-naphthyl)amine tramazoline 2-(5,6,7,8-Tetrahydro-1-naphthylamino)-2-imidazoline 4,5-Dihydro- BDBM50225288 Imidazolidin-2-ylidene-(5,6,7,8-tetrahydro-naphthalen-1-yl)-amine PDSP2_001082 Tobispray Tramazolinum 2-(5,6,7, 8-tetrahydro-1-naphthylimino)-imidazolidine 3715-90-0 (mono-hydrochloride) D08624 Muconasal (TN) Rhynaspray Tramazolina ZINC1534528 (4,5-Dihydro-1H-imidazol-2-yl)-(5,6,7,8-tetrahydro-naphthalen-1-yl)-amine 2-(5,6,7,8-tetrahydronaphthalen-1-ylamino)-2-imidazoline AC1L1KJB BCP29020 DTXSID5046936 N-tetralin-5-yl-4,5-dihydro-1H-imidazol-2-amine SLE31693IV Tramazoline (INN) 1082-57-1 2-[(5,6,7,8-Tetrahydro-1-naphthyl)amino]-2-imidazoline CHEBI:134893 Imidazolidine,2-[(5,6,7,8-tetrahydronaphthal-1-yl]imino- QQJLHRRUATVHED-UHFFFAOYSA-N Towk Tramazolinum [INN-Latin] 2-(5,6,7,8-tetrahydro-1-naphthylamino)-2-imidazoline 4,5-Dihydro-N-(5,6,7,8-tetrahydro-1-naphthalenyl)-1H-imidazol-2-amine AC1Q4UQJ D0ZT8D N-(5,6,7,8-Tetrahydro-1-naphthalenyl)-4,5-dihydro-1H-imidazol-2-amine # SCHEMBL121944 Tramazolina [INN-Spanish] 2-imidazolin-2-yl(5,6,7,8-tetrahydro-1-naphthyl)amine BDBM50027056 EINECS 214-105-6 PDSP1_001098 STL483756 Tramazoline [INN:BAN] 1H-Imidazol-2-amine, 4,5-dihydro-N-(5,6,7,8-tetrahydro-1-naphthalenyl)- 2-[(5,6,7,8-tetrahydronaphthalen-1-yl)amino]-2-imidazoline [ Show all ]
Inchi Key	QQJLHRRUATVHED-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H17N3/c1-2-6-11-10(4-1)5-3-7-12(11)16-13-14-8-9-15-13/h3,5,7H,1-2,4,6,8-9H2,(H2,14,15,16)
PubChem CID	5524
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50027056
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	275.42 nM	PMID9605427	BindingDB
Ki	275.423 nM	PMID9605427	PDSP

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