You can:
Name | 5-hydroxytryptamine receptor 1D |
---|---|
Species | Homo sapiens (Human) |
Gene | HTR1D |
Synonym | Serotonin 1D alpha receptor serotonin receptor 1D HTRL Htr1db 5-HT-1D [ Show all ] |
Disease | Acute migraine Epilepsy Migraine headaches Mood disorder Migraine [ Show all ] |
Length | 377 |
Amino acid sequence | MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS |
UniProt | P28221 |
Protein Data Bank | N/A |
GPCR-HGmod model | P28221 |
3D structure model | This predicted structure model is from GPCR-EXP P28221. |
BioLiP | N/A |
Therapeutic Target Database | T11072 |
ChEMBL | CHEMBL1983 |
IUPHAR | 3 |
DrugBank | BE0000659 |
Name | Fluspirilene |
---|---|
Molecular formula | C29H31F2N3O |
IUPAC name | 8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one |
Molecular weight | 475.584 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 1 |
XlogP | 5.6 |
Synonyms | NCGC00015424-03 ACM1841196 NCGC00016595-01 BRD-K77947974-001-04-9 Prestwick0_000906 [ Show all ] |
Inchi Key | QOYHHIBFXOOADH-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C29H31F2N3O/c30-24-12-8-22(9-13-24)27(23-10-14-25(31)15-11-23)7-4-18-33-19-16-29(17-20-33)28(35)32-21-34(29)26-5-2-1-3-6-26/h1-3,5-6,8-15,27H,4,7,16-21H2,(H,32,35) |
PubChem CID | 3396 |
ChEMBL | CHEMBL46516 |
IUPHAR | 85 |
BindingDB | 26948 |
DrugBank | DB04842 |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 1000.0 nM | PMID8935801 | IUPHAR |
Ki | 5000.0 nM | PMID8935801 | PDSP,BindingDB |
zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417