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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Histamine H4 receptor
Species	Homo sapiens (Human)
Gene	HRH4
Synonym	Pfi-013 SP9144 HH4R H4R H4 receptor GPRv53 GPCR105 G-protein coupled receptor 105 AXOR35 [ Show all ]
Disease	Allergic rhinitis Asthma Inflammatory disease Rheumatoid arthritis
Length	390
Amino acid sequence	MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
UniProt	Q9H3N8
Protein Data Bank	N/A
GPCR-HGmod model	Q9H3N8
3D structure model	This predicted structure model is from GPCR-EXP Q9H3N8.
BioLiP	N/A
Therapeutic Target Database	T26500
ChEMBL	CHEMBL3759
IUPHAR	265
DrugBank	BE0000146

Ligand

Name	CHEMBL1915024
Molecular formula	C16H16F3N5O
IUPAC name	4-[(3S)-3-aminopiperidin-1-yl]-9-(trifluoromethyl)-[1]benzofuro[3,2-d]pyrimidin-2-amine
Molecular weight	351.333
Hydrogen bond acceptor	9
Hydrogen bond donor	2
XlogP	2.6
Synonyms	SCHEMBL604433 BDBM50356835
Inchi Key	BNAXSGLGACVHDB-QMMMGPOBSA-N
Inchi ID	InChI=1S/C16H16F3N5O/c17-16(18,19)9-4-1-5-10-11(9)12-13(25-10)14(23-15(21)22-12)24-6-2-3-8(20)7-24/h1,4-5,8H,2-3,6-7,20H2,(H2,21,22,23)/t8-/m0/s1
PubChem CID	24826519
ChEMBL	CHEMBL1915024
IUPHAR	N/A
BindingDB	50356835
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID21920744	BindingDB,ChEMBL

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