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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Neuropeptide Y receptor type 2
Species	Homo sapiens (Human)
Gene	NPY2R
Synonym	NPY2-R NPY-Y2 receptor neuropeptide Y receptor type 2 Y2 receptor
Disease	Diabetes Metabolic disorders Obesity
Length	381
Amino acid sequence	MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV
UniProt	P49146
Protein Data Bank	N/A
GPCR-HGmod model	P49146
3D structure model	This predicted structure model is from GPCR-EXP P49146.
BioLiP	N/A
Therapeutic Target Database	T10670
ChEMBL	CHEMBL4018
IUPHAR	306
DrugBank	BE0002419

Ligand

Name	SMR000264080
Molecular formula	C23H18ClNO3
IUPAC name	[2-oxo-2-(2-phenylanilino)ethyl] (E)-3-(4-chlorophenyl)prop-2-enoate
Molecular weight	391.851
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	5.4
Synonyms	[2-oxo-2-(2-phenylanilino)ethyl] (E)-3-(4-chlorophenyl)prop-2-enoate (E)-3-(4-chlorophenyl)-2-propenoic acid [2-oxo-2-(2-phenylanilino)ethyl] ester HMS2549G19 AC1M7PPI CHEMBL1335124 (E)-3-(4-chlorophenyl)acrylic acid [2-keto-2-(2-phenylanilino)ethyl] ester MLS000409048 BDBM42557 [2-oxidanylidene-2-[(2-phenylphenyl)amino]ethyl] (E)-3-(4-chlorophenyl)prop-2-enoate cid_2446403 REGID_for_CID_2446403 [ Show all ]
Inchi Key	BMABHLCCGUBBJN-NTCAYCPXSA-N
Inchi ID	InChI=1S/C23H18ClNO3/c24-19-13-10-17(11-14-19)12-15-23(27)28-16-22(26)25-21-9-5-4-8-20(21)18-6-2-1-3-7-18/h1-15H,16H2,(H,25,26)/b15-12+
PubChem CID	2446403
ChEMBL	CHEMBL1335124
IUPHAR	N/A
BindingDB	42557
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	8058.0 nM	PubChem BioAssay data set	ChEMBL

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