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GPCR

Name	Histamine H1 receptor
Species	Homo sapiens (Human)
Gene	HRH1
Synonym	HH1R H1R Hisr H1 receptor
Disease	Vertigo's disease; Meniere's disease Ocular allergy Obesity Nausea; Vomiting Insomnia; Anxiety disorder Insomnia Hypersensitivity reactions; Coughs; Common colds Pain Parkinson's disease Perennial and seasonal allergic rhinitis; Vasomotor rhinitis; Allergic conjunctivitis Vertigo meniere's disease Unspecified Sleep disorders Seasonal and perennial allergic rhinitis and vasomotor rhinitis Rhinitis; Urticaria; Allergy Rhinitis Respiratory disease Respiratory allergies; Cancer Respiratory allergies; Allergic rhinitis Pruritus Nasal congestion Hay fever; Cough Hay fever; Allergic rhinitis Anxiety disorder Anesthesia Allergy Allergic skin disorders Allergic rhinitis; Urticaria; Pruritus Allergic rhinitis; Urticaria Allergic rhinitis Allergic disorders; Itching; Nausea Allergic conjunctivitis Anxiety disorder; Morning sickness Asthma Hay fever Common cold; Allergies Depression Dry cough [ Show all ]
Length	487
Amino acid sequence	MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS
UniProt	P35367
Protein Data Bank	3rze
GPCR-HGmod model	P35367
3D structure model	This structure is from PDB ID 3rze.
BioLiP	BL0202178, BL0202179, BL0202180
Therapeutic Target Database	T77913
ChEMBL	CHEMBL231
IUPHAR	262
DrugBank	BE0000442

Ligand

Name	7-OH-DPAT
Molecular formula	C16H25NO
IUPAC name	7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol
Molecular weight	247.382
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	4.1
Synonyms	2-Naphthalenol, 7-(dipropylamino)-5,6,7,8-tetrahydro- 7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-ol (DP-7-ADTN) 7-Ohdpat BRD-A18795974-001-01-2 D0XQ8N LS-94989 PDSP2_001627 [3H]7-OH-DPAT (+)7-OH-DPAT 7-Hydroxy-DPAT hydrobromide AC1Q7AGR CHEBI:111176 GTPL3296 NCGC00015494-05 (R,S) 7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-ol 7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol 7-OH-DPAT,(+) Biomol-NT_000011 CTK5E0721 L000014 NCGC00024742-03 SCHEMBL623950 (+)-7-(Dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol hydrobromide 2-Naphthalenol,7-(dipropylamino)-5,6,7,8-tetrahydro- 7-hydroxy-2-(dipropylamino)tetralin BRD-A18795974-004-02-4 D0Z4QZ N,N-Di-n-propyl-7-hydroxy-2-aminotetralin (+/-)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol 7-Hydroxy-N,N-di-n-propyl-2-aminotetralin AKOS015913437 GTPL950 NCGC00015494-06 7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-ol 7-OH-DPAT,(-) BPBio1_001143 D03PYX Lopac0_000616 PDSP1_001643 [3H]-7-OH-DPAT (+)-7-hydroxy-2-aminopropylaminotetralin 3-(dipropylamino)tetralin-6-ol 7-Hydroxy-2-N,N-dipropylaminotetralin AC1L1AZK CCG-204705 DP-7-AT NCGC00015494-04 (+/-)-7-hydroxy-2-(N,N-di-n-propylamino)tetralin 7-(Dipropylamino)-5,6,7,8-tetrahydro-2-naphthalenol BDBM50020222 CHEMBL285755 I14-4633 NCGC00024742-02 [ Show all ]
Inchi Key	BLYMJBIZMIGWFK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H25NO/c1-3-9-17(10-4-2)15-7-5-13-6-8-16(18)12-14(13)11-15/h6,8,12,15,18H,3-5,7,9-11H2,1-2H3
PubChem CID	1219
ChEMBL	CHEMBL285755
IUPHAR	3296, 950
BindingDB	50020222
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1500.0 nM	http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed	PDSP

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