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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(3) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD3
Synonym	dopaminergic receptor D3 D3R D3 receptor dopamine D3 receptor
Disease	Unspecified Emesis; Gastric motility disorder Female sexual dysfunction Male sexual disorders Psychotic disorders Cocaine addiction Schizophrenia Drug abuse [ Show all ]
Length	400
Amino acid sequence	MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
UniProt	P35462
Protein Data Bank	3pbl
GPCR-HGmod model	P35462
3D structure model	This structure is from PDB ID 3pbl.
BioLiP	BL0191566, BL0191567
Therapeutic Target Database	T02551
ChEMBL	CHEMBL234
IUPHAR	216
DrugBank	BE0000581

Ligand

Name	7-OH-DPAT
Molecular formula	C16H25NO
IUPAC name	7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol
Molecular weight	247.382
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	4.1
Synonyms	7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-ol (DP-7-ADTN) 7-Ohdpat BRD-A18795974-001-01-2 D0XQ8N LS-94989 PDSP2_001627 2-Naphthalenol, 7-(dipropylamino)-5,6,7,8-tetrahydro- 7-Hydroxy-DPAT hydrobromide AC1Q7AGR CHEBI:111176 GTPL3296 NCGC00015494-05 [3H]7-OH-DPAT (+)7-OH-DPAT 7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol 7-OH-DPAT,(+) Biomol-NT_000011 CTK5E0721 L000014 NCGC00024742-03 (R,S) 7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-ol 2-Naphthalenol,7-(dipropylamino)-5,6,7,8-tetrahydro- 7-hydroxy-2-(dipropylamino)tetralin BRD-A18795974-004-02-4 D0Z4QZ N,N-Di-n-propyl-7-hydroxy-2-aminotetralin SCHEMBL623950 (+)-7-(Dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol hydrobromide 7-Hydroxy-N,N-di-n-propyl-2-aminotetralin AKOS015913437 GTPL950 NCGC00015494-06 (+/-)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol 7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-ol 7-OH-DPAT,(-) BPBio1_001143 D03PYX Lopac0_000616 PDSP1_001643 3-(dipropylamino)tetralin-6-ol 7-Hydroxy-2-N,N-dipropylaminotetralin AC1L1AZK CCG-204705 DP-7-AT NCGC00015494-04 [3H]-7-OH-DPAT (+)-7-hydroxy-2-aminopropylaminotetralin 7-(Dipropylamino)-5,6,7,8-tetrahydro-2-naphthalenol BDBM50020222 CHEMBL285755 I14-4633 NCGC00024742-02 (+/-)-7-hydroxy-2-(N,N-di-n-propylamino)tetralin [ Show all ]
Inchi Key	BLYMJBIZMIGWFK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H25NO/c1-3-9-17(10-4-2)15-7-5-13-6-8-16(18)12-14(13)11-15/h6,8,12,15,18H,3-5,7,9-11H2,1-2H3
PubChem CID	1219
ChEMBL	CHEMBL285755
IUPHAR	3296, 950
BindingDB	50020222
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	0.531 nM	PMID18410082	BindingDB,ChEMBL
EC50	0.95 nM	PMID23018094	BindingDB
Emax	45.3 %	PMID18410082	ChEMBL
Kd	0.27 nM	PMID7759603	IUPHAR
Ki	0.39 nM	PMID7756621	PDSP
Ki	1.4 nM	, Bioorg. Med. Chem. Lett., (1997) 7:21:2759	BindingDB,ChEMBL
Ki	1.49 nM	PMID27035329	ChEMBL
Ki	1.5 nM	PMID27035329	BindingDB
Ki	1.58 nM	PMID10611634	PDSP,BindingDB
Ki	1.6 nM	PMID8301582	PDSP,BindingDB
Ki	1.75 nM	PMID27035329	ChEMBL
Ki	1.8 nM	PMID27035329	BindingDB
Ki	2.1 nM	PMID7756621	PDSP
Ki	2.19 nM	PMID10832613	PDSP,BindingDB
Ki	2.35 nM	PMID20146482	BindingDB,ChEMBL
Ki	2.4 nM	PMID9067310	PDSP,BindingDB
Ki	2.9 nM	PMID7990123	BindingDB,ChEMBL
Ki	3.02 nM	PMID10832613	PDSP
Ki	3.6 nM	PMID18834111	BindingDB,ChEMBL
Ki	3.98 - 79.4 nM	PMID8301582, PMID7756621, PMID7907989, PMID7576010, PMID7990123	IUPHAR
Ki	4.37 nM	PMID10832613	PDSP,BindingDB
Ki	6.9 nM	PMID23018094	BindingDB
Ki	55.6 nM	PMID9067310	PDSP,BindingDB

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