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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(2) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R Dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61169
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL339
IUPHAR	215
DrugBank	N/A

Ligand

Name	7-OH-DPAT
Molecular formula	C16H25NO
IUPAC name	7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol
Molecular weight	247.382
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	4.1
Synonyms	L000014 NCGC00024742-03 (R,S) 7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-ol 7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol 7-OH-DPAT,(+) Biomol-NT_000011 CTK5E0721 D0Z4QZ N,N-Di-n-propyl-7-hydroxy-2-aminotetralin SCHEMBL623950 (+)-7-(Dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol hydrobromide 2-Naphthalenol,7-(dipropylamino)-5,6,7,8-tetrahydro- 7-hydroxy-2-(dipropylamino)tetralin BRD-A18795974-004-02-4 GTPL950 NCGC00015494-06 (+/-)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol 7-Hydroxy-N,N-di-n-propyl-2-aminotetralin AKOS015913437 D03PYX Lopac0_000616 PDSP1_001643 7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-ol 7-OH-DPAT,(-) BPBio1_001143 DP-7-AT NCGC00015494-04 [3H]-7-OH-DPAT (+)-7-hydroxy-2-aminopropylaminotetralin 3-(dipropylamino)tetralin-6-ol 7-Hydroxy-2-N,N-dipropylaminotetralin AC1L1AZK CCG-204705 I14-4633 NCGC00024742-02 (+/-)-7-hydroxy-2-(N,N-di-n-propylamino)tetralin 7-(Dipropylamino)-5,6,7,8-tetrahydro-2-naphthalenol BDBM50020222 CHEMBL285755 D0XQ8N LS-94989 PDSP2_001627 2-Naphthalenol, 7-(dipropylamino)-5,6,7,8-tetrahydro- 7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-ol (DP-7-ADTN) 7-Ohdpat BRD-A18795974-001-01-2 GTPL3296 NCGC00015494-05 [3H]7-OH-DPAT (+)7-OH-DPAT 7-Hydroxy-DPAT hydrobromide AC1Q7AGR CHEBI:111176 [ Show all ]
Inchi Key	BLYMJBIZMIGWFK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H25NO/c1-3-9-17(10-4-2)15-7-5-13-6-8-16(18)12-14(13)11-15/h6,8,12,15,18H,3-5,7,9-11H2,1-2H3
PubChem CID	1219
ChEMBL	CHEMBL285755
IUPHAR	950, 3296
BindingDB	50020222
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1.88 nM	Med Chem Res, (2004) 13:1:25	ChEMBL
Emax	39.0 %	Med Chem Res, (2004) 13:1:25	ChEMBL
IC50	30.0 nM	PMID2903247	BindingDB,ChEMBL
IC50	180.0 nM	Med Chem Res, (2004) 13:1:25	ChEMBL
IC50	192.0 nM	Med Chem Res, (2004) 13:1:25	ChEMBL
Ki	2.5 nM	, Bioorg. Med. Chem. Lett., (1997) 7:21:2759	BindingDB,ChEMBL
Ki	9.4 nM	PMID10327430	BindingDB
Ki	54.0 nM	PMID7932553, PMID8230131	BindingDB,ChEMBL
Ki	69.9 nM	PMID10327430	BindingDB
Ki	142.0 nM	PMID8098771	BindingDB,ChEMBL
Ki	202.0 nM	PMID18410082	BindingDB,ChEMBL
Ki	311.0 nM	PMID20605099, PMID19427222, PMID19053758	BindingDB,ChEMBL
Ki	380.0 nM	PMID10327430	BindingDB
Ki	630.957 nM	PMID7990123	IUPHAR

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