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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	P2Y purinoceptor 2
Species	Homo sapiens (Human)
Gene	P2RY2
Synonym	Purinergic receptor purinergic receptor P2Y P2Y2 receptor P2Y2 P2Y purinoceptor 2 P2Y ATP receptor 2 P2U1 P2U receptor 1 P2U purinoceptor 1 ATP receptor [ Show all ]
Disease	Dry eye disease Constipation Cystic fibrosis Lung cancer
Length	377
Amino acid sequence	MAADLGPWNDTINGTWDGDELGYRCRFNEDFKYVLLPVSYGVVCVPGLCLNAVALYIFLCRLKTWNASTTYMFHLAVSDALYAASLPLLVYYYARGDHWPFSTVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLRSLRWGRARYARRVAGAVWVLVLACQAPVLYFVTTSARGGRVTCHDTSAPELFSRFVAYSSVMLGLLFAVPFAVILVCYVLMARRLLKPAYGTSGGLPRAKRKSVRTIAVVLAVFALCFLPFHVTRTLYYSFRSLDLSCHTLNAINMAYKVTRPLASANSCLDPVLYFLAGQRLVRFARDAKPPTGPSPATPARRRLGLRRSDRTDMQRIEDVLGSSEDSRRTESTPAGSENTKDIRL
UniProt	P41231
Protein Data Bank	N/A
GPCR-HGmod model	P41231
3D structure model	This predicted structure model is from GPCR-EXP P41231.
BioLiP	N/A
Therapeutic Target Database	T93515
ChEMBL	CHEMBL4398
IUPHAR	324
DrugBank	BE0002401

Ligand

Name	uridine 5'-triphosphate
Molecular formula	C9H15N2O15P3
IUPAC name	[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
Molecular weight	484.139
Hydrogen bond acceptor	15
Hydrogen bond donor	7
XlogP	-5.8
Synonyms	Uridine5'-(tetrahydrogen triphosphate) 5'-UTP [(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl (hydroxy-phosphonooxyphosphoryl) hydrogen phosphate AN-41856 CHEBI:15713 D0Z7FU GTPL1734 KBio2_002177 NINDS_000269 Spectrum_001697 Uridine 5'-triphosphoric acid UT0S826Z60 AC1L1LV9 [[[5-(2,4-Dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid bmse000295 CS-7777 DC99D596-4755-4E87-B3AA-F1D6CFEDCE9A I14-101793 KBio3_002692 SPBio_000509 uridine 5''-triphosphoric acid uridine tetrahydrogen triphosphate 266356-22-3 5''-UTP VZ34081 AK122022 C00075 D0W1XX EINECS 200-558-7 INS316 LS-160841 Spectrum4_000851 ((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate Uridine, mono(tetrahydrogen triphosphate) (ester) uridine5'-triphosphate [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate AX8156257 DB-054470 H4utp KBio2_004745 PGAVKCOVUIYSFO-XVFCMESISA-N UNII-UT0S826Z60 Uridine 5_-triphosphate 19817-92-6 3h-uridine triphosphate Uteplex AC1Q1I4F BRN 0071520 CTK5B8994 DivK1c_000269 IDI1_000269 KBioGR_001481 Spectrum2_000525 Uridine 5'-(tetrahydrogen triphosphate) uridine triphosphate 5'-URIDYLATE TRIPHOSPHATE ZINC3861755 AKOS016011172 C9H15N2O15P3 D0Y1ZP FT-0631282 KBio1_000269 NCGC00163323-01 Spectrum5_001167 Uridine 5'-triphosphate sodium salt, AldrichCPR 063U398 uridine-5'-triphosphate uridintriphosphat 63-39-8 [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate BDBM50118213 CHEMBL336296 DB04005 HY-107372 KBio2_007313 SCHEMBL76682 uridine 5''-(tetrahydrogen triphosphate) Uridine mono(tetrahydrogen triphosphate) 2,4(1H,3H)-Pyrimidinedione, 1-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-.beta.-D-ribofuranosyl]- 4-24-00-01222 (Beilstein Handbook Reference) UTP AJ-75025 BSPBio_003192 D0W1NH DTXSID0041147 INS 316 KBioSS_002177 Spectrum3_001596 Uridine 5'-(tetrahydrogen triphosphate) (8CI,9CI) Uridine, 5'-(tetrahydrogen triphosphate) [ Show all ]
Inchi Key	PGAVKCOVUIYSFO-XVFCMESISA-N
Inchi ID	InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
PubChem CID	6133
ChEMBL	CHEMBL336296
IUPHAR	1734
BindingDB	50118213
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<300000.0 nM	PMID19419204	ChEMBL
EC50	7.0 nM	PMID17079144, PMID17011188	BindingDB,ChEMBL
EC50	7.94328 nM	PMID8564228, PMID11754592	IUPHAR
EC50	17.9 nM	PMID21417463	ChEMBL
EC50	18.0 nM	PMID21417463	BindingDB
EC50	20.0 nM	PMID22386981	BindingDB,ChEMBL
EC50	30.0 nM	PMID11206448	BindingDB,ChEMBL
EC50	37.2 nM	PMID19419204	ChEMBL
EC50	43.0 nM	PMID17125260	BindingDB,ChEMBL
EC50	49.0 nM	PMID17302398	BindingDB,ChEMBL
EC50	50.1 nM	PMID19419204	ChEMBL
EC50	55.0 nM	PMID21528910	BindingDB,ChEMBL
EC50	59.0 nM	PMID19419204	BindingDB,ChEMBL
EC50	60.0 nM	PMID21528910, PMID20446735, PMID18514530	BindingDB,ChEMBL
EC50	80.4 nM	PMID19419204	BindingDB,ChEMBL
EC50	100.0 nM	PMID20095577	BindingDB,ChEMBL
EC50	108.0 nM	PMID19419204	ChEMBL
EC50	109.65 nM	PMID17941622	ChEMBL
EC50	121.0 nM	PMID19419204	ChEMBL
EC50	124.0 nM	PMID19419204	ChEMBL
EC50	138.0 nM	PMID19419204	ChEMBL
EC50	140.0 nM	PMID12213051, PMID22901672	BindingDB,ChEMBL
EC50	157.0 nM	PMID19419204	ChEMBL
EC50	450.0 nM	PMID16539385	BindingDB,ChEMBL
EC50	640.0 nM	PMID22107038, PMID18760862	BindingDB,ChEMBL
EC50	781.0 nM	PMID19419204	BindingDB,ChEMBL
EC50	2090.0 nM	PMID19419204	ChEMBL
EC50	20600.0 nM	PMID19419204	ChEMBL
Efficacy	3.0 %	PMID19419204	ChEMBL
Efficacy	43.0 %	PMID19419204	ChEMBL
Efficacy	86.0 %	PMID19419204	ChEMBL
Efficacy	99.0 %	PMID19419204	ChEMBL
Efficacy	100.0 %	PMID19419204	ChEMBL
Efficacy	107.0 %	PMID19419204	ChEMBL
Efficacy	109.0 %	PMID19419204	ChEMBL
Efficacy	127.0 %	PMID19419204	ChEMBL
Efficacy	128.0 %	PMID19419204	ChEMBL
Efficacy	130.0 %	PMID19419204	ChEMBL
Efficacy	133.0 %	PMID19419204	ChEMBL
Efficacy	138.0 %	PMID19419204	ChEMBL
Ratio EC50	2.0 -	PMID19419204	ChEMBL
Ratio EC50	5.0 -	PMID21528910	ChEMBL
Ratio EC50	25.0 -	PMID19419204	ChEMBL

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