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Name | Growth hormone secretagogue receptor type 1 |
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Species | Rattus norvegicus (Rat) |
Gene | Ghsr |
Synonym | GH-releasing peptide receptor Ghrelin receptor ghrelin receptor 1a GHRP GHS-R [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 364 |
Amino acid sequence | MWNATPSEEPEPNVTLDLDWDASPGNDSLPDELLPLFPAPLLAGVTATCVALFVVGISGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVILVIWAVAFCSAGPIFVLVGVEHENGTDPRDTNECRATEFAVRSGLLTVMVWVSSVFFFLPVFCLTVLYSLIGRKLWRRRGDAAVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFKLLGFESFSQRKLSTLKDESSRAWTKSSINT |
UniProt | O08725 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3278 |
IUPHAR | 246 |
DrugBank | N/A |
Name | CHEMBL1080320 |
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Molecular formula | C24H22N4O2S |
IUPAC name | [(3S)-4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl]-[4-(1,3-thiazol-5-yl)phenyl]methanone |
Molecular weight | 430.526 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 1 |
XlogP | 3.6 |
Synonyms | BDBM50312795 (S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(4-(thiazol-5-yl)phenyl)methanone |
Inchi Key | ORTRFLDHPXAUHU-INIZCTEOSA-N |
Inchi ID | InChI=1S/C24H22N4O2S/c1-16-14-27(23(29)19-5-3-18(4-6-19)22-13-25-15-31-22)10-11-28(16)24(30)20-7-2-17-8-9-26-21(17)12-20/h2-9,12-13,15-16,26H,10-11,14H2,1H3/t16-/m0/s1 |
PubChem CID | 46880812 |
ChEMBL | CHEMBL1080320 |
IUPHAR | N/A |
BindingDB | 50312795 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Activity | 5.0 % | PMID20137933 | ChEMBL |
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