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GLASS

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GPCR

Name	D(3) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD3
Synonym	dopaminergic receptor D3 D3R D3 receptor dopamine D3 receptor
Disease	Unspecified Emesis; Gastric motility disorder Female sexual dysfunction Male sexual disorders Psychotic disorders Cocaine addiction Schizophrenia Drug abuse [ Show all ]
Length	400
Amino acid sequence	MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
UniProt	P35462
Protein Data Bank	3pbl
GPCR-HGmod model	P35462
3D structure model	This structure is from PDB ID 3pbl.
BioLiP	BL0191566, BL0191567
Therapeutic Target Database	T02551
ChEMBL	CHEMBL234
IUPHAR	216
DrugBank	BE0000581

Ligand

Name	CHEMBL380054
Molecular formula	C18H19FN4
IUPAC name	2-[[4-(4-fluorophenyl)piperazin-1-yl]methyl]imidazo[1,2-a]pyridine
Molecular weight	310.376
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	3.3
Synonyms	SR-01000288123 AC1LOW22 ZINC4628996 2-[[4-(4-fluorophenyl)piperazin-1-yl]methyl]imidazo[1,2-a]pyridine MCULE-6071808291 SR-01000288123-1 2-((4-(4-fluorophenyl)piperazin-1-yl)methyl)imidazo[1,2-a]pyridine AKOS002219664 2-{[4-(4-fluorophenyl)piperazin-1-yl]methyl}imidazo[1,2-a]pyridine MolPort-000-241-499 A3639/0154442 STK684879 2-[4-(4-fluorophenyl)piperazin-1-ylmethyl]imidazo[1,2-a]pyridine BDBM50189837 F3308-0241 2-{[4-(4-fluorophenyl)piperazino]methyl}imidazo[1,2-a]pyridine [ Show all ]
Inchi Key	BIARYCFROFVWEW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H19FN4/c19-15-4-6-17(7-5-15)22-11-9-21(10-12-22)13-16-14-23-8-2-1-3-18(23)20-16/h1-8,14H,9-13H2
PubChem CID	1248739
ChEMBL	CHEMBL380054
IUPHAR	N/A
BindingDB	50189837
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	3100.0 nM	PMID16789750	BindingDB,ChEMBL

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