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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Neuropeptide Y receptor type 2
Species	Homo sapiens (Human)
Gene	NPY2R
Synonym	NPY2-R NPY-Y2 receptor neuropeptide Y receptor type 2 Y2 receptor
Disease	Diabetes Metabolic disorders Obesity
Length	381
Amino acid sequence	MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV
UniProt	P49146
Protein Data Bank	N/A
GPCR-HGmod model	P49146
3D structure model	This predicted structure model is from GPCR-EXP P49146.
BioLiP	N/A
Therapeutic Target Database	T10670
ChEMBL	CHEMBL4018
IUPHAR	306
DrugBank	BE0002419

Ligand

Name	CHEMBL3104198
Molecular formula	C28H37F3N4O2
IUPAC name	N-[4-[4-[2-(diethylamino)-1-(3,4-difluorophenyl)-2-oxoethyl]piperazin-1-yl]-3-fluorophenyl]-2-ethylbutanamide
Molecular weight	518.625
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	5.0
Synonyms	BDBM50445639 SCHEMBL5079893
Inchi Key	BHTQTYWKLPJAQN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H37F3N4O2/c1-5-19(6-2)27(36)32-21-10-12-25(24(31)18-21)34-13-15-35(16-14-34)26(28(37)33(7-3)8-4)20-9-11-22(29)23(30)17-20/h9-12,17-19,26H,5-8,13-16H2,1-4H3,(H,32,36)
PubChem CID	58870763
ChEMBL	CHEMBL3104198
IUPHAR	N/A
BindingDB	50445639
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	330.0 nM	PMID24365162	BindingDB,ChEMBL

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