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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Hydroxycarboxylic acid receptor 2
Species	Rattus norvegicus (Rat)
Gene	Hcar2
Synonym	Protein PUMA-G Nicotinic acid receptor Nic1 Niacr1 niacin receptor 1 HCA2 receptor G-protein coupled receptor HM74A G-protein coupled receptor HM74 G-protein coupled receptor 109A G-protein coupled receptor 109 G protein-coupled receptor 109A PUMAG [ Show all ]
Disease	N/A for non-human GPCRs
Length	360
Amino acid sequence	MSKQNHFLVINGKNCCVFRDENIAKVLPPVLGLEFVFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLTDNYVQNWDWRFGSIPCRVMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHFLNKISNRTAAIISCFLWGITIGLTVHLLYTDMMTRNGDANLCSSFSICYTFRWHDAMFLLEFFLPLGIILFCSGRIIWSLRQRQMDRHVKIKRAINFIMVVAIVFVICFLPSVAVRIRIFWLLYKHNVRNCDIYSSVDLAFFTTLSFTYMNSMLDPVVYYFSSPSFPNFFSTCINRCLRRKTLGEPDNNRSTSVELTGDPSTIRSIPGALMTDPSEPGSPPYLASTSR
UniProt	Q80Z39
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4731
IUPHAR	312
DrugBank	N/A

Ligand

Name	3-(4-methylphenyl)-1H-pyrazole-5-carboxylic acid
Molecular formula	C11H10N2O2
IUPAC name	3-(4-methylphenyl)-1H-pyrazole-5-carboxylic acid
Molecular weight	202.213
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	2.1
Synonyms	5-(4-Methylphenyl)pyrazole-3-carboxylic Acid AB20803 BAS 06804298 cid_818267 J-510735 MFCD04209141 SCHEMBL1413993 VU0607278-1 3-(p-Tolyl)-1H-pyrazole-5-carboxylic acid 46413-67-6 5-p-tolyl-2 h-pyrazole-3-carboxylic acid AF-399/40987696 BDBM50132133 EN300-26176 KB-27161 MolPort-000-474-042 ST24041640 1H-Pyrazole-3-carboxylic acid, 5-(4-methylphenyl)- 5-(4-Methylphenyl)-1H-pyrazole-3-carboxylic acid, AldrichCPR 890007-12-2 AKOS000271407 HTS000458 KS-00003HQT RTR-027992 TOS-BB-0267 3-(4-Methylphenyl)-1H-pyrazole-5-carboxylic acid, AldrichCPR 3-p-tolyl-1h-pyrazole-5-carboxylic acid 5-(p-Tolyl)-1H-pyrazole-3-carboxylic acid AC1LGAYW BB 0217970 CTK1D5064 KB-108591 MLS-0091963.0001 SCHEMBL15094586 Z57683741 4693AC 5-p-Tolyl-2H-pyrazole-3-carboxylic acid AJ-70376 BGTWUOQARPOYER-UHFFFAOYSA-N F3250-0576 KM2794 MolPort-000-772-839 ST4140388 1H-Pyrazole-5-carboxylic acid, 3-(4-methylphenyl)- 5-(4-methylphenyl)-2H-pyrazole-3-carboxylic acid AB0001096 ALBB-006819 CHEMBL341154 I04-4283 MCULE-7007143054 SBB006942 TR-027992 3-(4-methylphenyl)pyrazole-5-carboxylic acid 3-p-Tolyl-1H-pyrazole-5-carboxylic acid, AldrichCPR 5-p-Tolyl-1H-pyrazole-3-carboxylic acid AC1Q2KES BBL008302 DTXSID10355932 KB-243673 MLS000124028 SMR000124591 ZINC5126258 5-(4-methylphenyl)-1h-pyrazole-3-carboxylic acid AKOS000263469 BS-4122 FT-0677278 KS-00001NGQ NE12837 STK299946 [ Show all ]
Inchi Key	BGTWUOQARPOYER-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H10N2O2/c1-7-2-4-8(5-3-7)9-6-10(11(14)15)13-12-9/h2-6H,1H3,(H,12,13)(H,14,15)
PubChem CID	818267
ChEMBL	CHEMBL341154
IUPHAR	N/A
BindingDB	50132133
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	37900.0 nM	PMID12930155	BindingDB,ChEMBL

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