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GPCR

Name	Alpha-2A adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA2A
Synonym	alpha2D alpha2A-AR alpha2A-adrenoceptor alpha2A-adrenergic receptor alpha2A Alpha-2AAR Adra-2 Adra-2a ADRA2 ADRA2R Adrenergic alpha 2A receptor adrenergic receptor Alpha-2 adrenergic receptor subtype C10 Alpha-2A adrenoceptor Alpha-2A adrenoreceptor [ Show all ]
Disease	Attention deficit hyperactivity disorder Sexual dysfunction Pain
Length	450
Amino acid sequence	MGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
UniProt	P08913
Protein Data Bank	N/A
GPCR-HGmod model	P08913
3D structure model	This predicted structure model is from GPCR-EXP P08913.
BioLiP	N/A
Therapeutic Target Database	T11448
ChEMBL	CHEMBL1867
IUPHAR	25
DrugBank	BE0000289

Ligand

Name	76537-53-6
Molecular formula	C10H13N5
IUPAC name	8-piperazin-1-ylimidazo[1,2-a]pyrazine
Molecular weight	203.249
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	0.5
Synonyms	8-(1-Piperazinyl)imidazo(1,2-a)pyrazine AC1Q1I52 DTXSID50227346 8-Pdpr BDBM50002151 Imidazo[1,2-a]pyrazine, 8-(1-piperazinyl)- A839966 CTK5E3085 SCHEMBL5496661 8-(1-piperazinyl)imidazo[1,2-a]pyrazine AC1Q4X6M FT-0756627 8-Piperazin-1-yl-imidazo[1,2-a]pyrazine Imidazo[1,2-a]pyrazine,8-(1-piperazinyl)- AC1L2YVL D0E5CI ZINC5117657 8-(piperazin-1-yl)imidazo[1,2-a]pyrazine AKOS024075563 Imidazo(1,2-a)pyrazine, 8-(1-piperazinyl)- 1-{IMIDAZO[1,2-A]PYRAZIN-8-YL}PIPERAZINE 8-piperazin-1-ylimidazo[1,2-a]pyrazine CHEMBL331036 L-639,019 [ Show all ]
Inchi Key	NSHLOJVJEGEMSF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H13N5/c1-5-14(6-2-11-1)9-10-13-4-8-15(10)7-3-12-9/h3-4,7-8,11H,1-2,5-6H2
PubChem CID	131268
ChEMBL	CHEMBL331036
IUPHAR	N/A
BindingDB	50002151
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	35.0 nM	PMID1656026	BindingDB

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