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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 2B
Species	Homo sapiens (Human)
Gene	HTR2B
Synonym	stomach fundus serotonin receptor serotonin receptor 2B 5-HT2F 5-HT-2B 5-HT2B 5-HT2B receptor 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled [ Show all ]
Disease	Psychoses Migraine Irritable bowel syndrome Depression; Cerebral infarction Coronary heart disease Congestive heart failure Pulmonary arterial hypertension [ Show all ]
Length	481
Amino acid sequence	MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV
UniProt	P41595
Protein Data Bank	5tud, 5tvn, 6drx, 4ib4, 4nc3, 6dry, 6drz, 6ds0
GPCR-HGmod model	P41595
3D structure model	This structure is from PDB ID 5tud.
BioLiP	BL0425280, BL0425283, BL0425282, BL0239858, BL0239859, BL0265182, BL0265183, BL0368464, BL0425281, BL0385686,BL0385687, BL0425284, BL0425285, BL0425286, BL0368465, BL0425287
Therapeutic Target Database	T31204
ChEMBL	CHEMBL1833
IUPHAR	7
DrugBank	BE0000393

Ligand

Name	suloctidil
Molecular formula	C20H35NOS
IUPAC name	(1S,2R)-2-(octylamino)-1-(4-propan-2-ylsulfanylphenyl)propan-1-ol
Molecular weight	337.566
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	5.8
Synonyms	Opera_ID_1631 ST51015124 (1S,2R)-1-[4-(isopropylthio)phenyl]-2-(octylamino)propan-1-ol AC1LCW9C CHEBI:92751 HMS2230I12 SBB058183 Suloctidil, analytical standard, for drug analysis (1S,2R)-2-(octylamino)-1-[4-(propan-2-ylthio)phenyl]-1-propanol BPBio1_000444 cid_657255 MLS000028666 MLS002695978 SR-01000000281 54767-75-8 BSPBio_000402 GNF-Pf-1859 Prestwick3_000421 (1S,2R)-1-[4-(methylethylthio)phenyl]-2-(octylamino)propan-1-ol AKOS024374991 HMS3713E04 MLS001148124 SCHEMBL13613541 UNII-XV1N1XY17K component BFCDFTHTSVTWOG-YLJYHZDGSA-N (alphaS)-alpha-[(R)-1-(Octylamino)ethyl]-4-[(1-methylethyl)thio]benzenemethanol BRD-K42635745-001-02-4 CS-4883 NCGC00022213-03 SR-01000000281-3 (1S,2R)-1-(4-(isopropylthio)phenyl)-2-(octylamino)propan-1-ol AB00383060 CCG-220421 HMS2096E04 REGID_for_CID_657255 Suloctidil (USAN/INN) (1S,2R)-2-(octylamino)-1-(4-propan-2-ylsulfanylphenyl)propan-1-ol BDBM67714 CHEMBL588119 HY-B1237 MLS002222281 SMR000058933 ZINC2561289 (R,S)-4-((1-Methylethyl)thio)-alpha-(1-(octylamino)ethyl)benzenemethanol BRD-K42635745-001-22-2 D05967 [ Show all ]
Inchi Key	BFCDFTHTSVTWOG-YLJYHZDGSA-N
Inchi ID	InChI=1S/C20H35NOS/c1-5-6-7-8-9-10-15-21-17(4)20(22)18-11-13-19(14-12-18)23-16(2)3/h11-14,16-17,20-22H,5-10,15H2,1-4H3/t17-,20-/m1/s1
PubChem CID	657255
ChEMBL	CHEMBL588119
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	939.0 nM	DrugMatrix in vitro pharmacology data	ChEMBL
Ki	597.5 nM	DrugMatrix in vitro pharmacology data	ChEMBL

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