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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	G-protein coupled receptor 4
Species	Homo sapiens (Human)
Gene	GPR4
Synonym	G-protein coupled receptor 19 GPR19 GPR4
Disease	N/A
Length	362
Amino acid sequence	MGNHTWEGCHVDSRVDHLFPPSLYIFVIGVGLPTNCLALWAAYRQVQQRNELGVYLMNLSIADLLYICTLPLWVDYFLHHDNWIHGPGSCKLFGFIFYTNIYISIAFLCCISVDRYLAVAHPLRFARLRRVKTAVAVSSVVWATELGANSAPLFHDELFRDRYNHTFCFEKFPMEGWVAWMNLYRVFVGFLFPWALMLLSYRGILRAVRGSVSTERQEKAKIKRLALSLIAIVLVCFAPYHVLLLSRSAIYLGRPWDCGFEERVFSAYHSSLAFTSLNCVADPILYCLVNEGARSDVAKALHNLLRFLASDKPQEMANASLTLETPLTSKRNSTAKAMTGSWAATPPSQGDQVQLKMLPPAQ
UniProt	P46093
Protein Data Bank	N/A
GPCR-HGmod model	P46093
3D structure model	This predicted structure model is from GPCR-EXP P46093.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3638324
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL3675734
Molecular formula	C24H32N4O2
IUPAC name	4-[2-[4-[(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenoxy]ethyl]piperidin-4-ol
Molecular weight	408.546
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	3.5
Synonyms	US8748435, 25 BDBM123500 SCHEMBL12802744
Inchi Key	NEJYDAFQMGJVDI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H32N4O2/c1-4-22-21(23-26-17(2)15-18(3)28(23)27-22)16-19-5-7-20(8-6-19)30-14-11-24(29)9-12-25-13-10-24/h5-8,15,25,29H,4,9-14,16H2,1-3H3
PubChem CID	68379216
ChEMBL	CHEMBL3675734
IUPHAR	N/A
BindingDB	123500
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	110.0 nM	, None	BindingDB,ChEMBL

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