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GLASS

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GPCR

Name	Neuropeptide Y receptor type 2
Species	Homo sapiens (Human)
Gene	NPY2R
Synonym	NPY2-R NPY-Y2 receptor neuropeptide Y receptor type 2 Y2 receptor
Disease	Diabetes Metabolic disorders Obesity
Length	381
Amino acid sequence	MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV
UniProt	P49146
Protein Data Bank	N/A
GPCR-HGmod model	P49146
3D structure model	This predicted structure model is from GPCR-EXP P49146.
BioLiP	N/A
Therapeutic Target Database	T10670
ChEMBL	CHEMBL4018
IUPHAR	306
DrugBank	BE0002419

Ligand

Name	MLS000089771
Molecular formula	C23H30N2O2
IUPAC name	1-[4-(4-methylphenyl)piperazin-1-yl]-3-(2-prop-2-enylphenoxy)propan-2-ol
Molecular weight	366.505
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	4.3
Synonyms	CHEMBL1548605 SMR000024389 1-[4-(4-methylphenyl)-1-piperazinyl]-3-(2-prop-2-enylphenoxy)-2-propanol AC1MME82 MCULE-3891300974 BDBM61795 MolPort-007-560-794 1-(2-allylphenoxy)-3-[4-(4-methylphenyl)piperazin-1-yl]propan-2-ol cid_3237370 SR-01000460024 1-[4-(4-methylphenyl)piperazin-1-yl]-3-(2-prop-2-enylphenoxy)propan-2-ol AKOS001644934 Oprea1_031090 1-(2-allylphenoxy)-3-[4-(p-tolyl)piperazino]propan-2-ol HMS2471N17 SR-01000460024-1 AKOS021994733 MLS002585143 [ Show all ]
Inchi Key	BEYGANIWMHXXHZ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H30N2O2/c1-3-6-20-7-4-5-8-23(20)27-18-22(26)17-24-13-15-25(16-14-24)21-11-9-19(2)10-12-21/h3-5,7-12,22,26H,1,6,13-18H2,2H3
PubChem CID	3237370
ChEMBL	CHEMBL1548605
IUPHAR	N/A
BindingDB	61795
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	14805.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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