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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	MLS003271268
Molecular formula	C22H27N7O4
IUPAC name	(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-N-methyl-N-[(1-methyl-3,4-dihydro-2H-quinolin-6-yl)methyl]oxolane-2-carboxamide
Molecular weight	453.503
Hydrogen bond acceptor	9
Hydrogen bond donor	3
XlogP	0.3
Synonyms	(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-N-methyl-N-[(1-methyl-3,4-dihydro-2H-quinolin-6-yl)methyl]-2-oxolanecarboxamide cid_51360281 (2S,3S,4R,5R)-5-adenin-9-yl-3,4-dihydroxy-N-methyl-N-[(1-methyl-3,4-dihydro-2H-quinolin-6-yl)methyl]tetrahydrofuran-2-carboxamide (2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-N-methyl-N-[(1-methyl-3,4-dihydro-2H-quinolin-6-yl)methyl]oxolane-2-carboxamide CHEMBL2130641 (2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-N-methyl-N-[(1-methyl-3,4-dihydro-2H-quinolin-6-yl)methyl]-3,4-bis(oxidanyl)oxolane-2-carboxamide SMR001950863 BDBM97189 [ Show all ]
Inchi Key	BEEKFKNMYOAQGU-RQXXJAGISA-N
Inchi ID	InChI=1S/C22H27N7O4/c1-27-7-3-4-13-8-12(5-6-14(13)27)9-28(2)21(32)18-16(30)17(31)22(33-18)29-11-26-15-19(23)24-10-25-20(15)29/h5-6,8,10-11,16-18,22,30-31H,3-4,7,9H2,1-2H3,(H2,23,24,25)/t16-,17+,18-,22+/m0/s1
PubChem CID	51360281
ChEMBL	CHEMBL2130641
IUPHAR	N/A
BindingDB	97189
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	3974.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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