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GPCR

Name	fMet-Leu-Phe receptor
Species	Homo sapiens (Human)
Gene	FPR1
Synonym	NFPR N-formylpeptide chemoattractant receptor N-formyl peptide receptor FPR1 FPR formyl peptide receptor 1 fMLP receptor fMLF-R [ Show all ]
Disease	Inflammatory disease Peptic ulcer
Length	350
Amino acid sequence	METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
UniProt	P21462
Protein Data Bank	N/A
GPCR-HGmod model	P21462
3D structure model	This predicted structure model is from GPCR-EXP P21462.
BioLiP	N/A
Therapeutic Target Database	T87831
ChEMBL	CHEMBL3359
IUPHAR	222
DrugBank	BE0000995

Ligand

Name	cid_654635
Molecular formula	C25H23NO6
IUPAC name	5-(4-hydroxy-3-methoxyphenyl)-4-(5-methylfuran-2-carbonyl)-1-(2-phenylethyl)pyrrolidine-2,3-dione
Molecular weight	433.46
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	3.8
Synonyms	4-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-[(5-methyl-2-furanyl)-oxomethyl]-1-(2-phenylethyl)-2H-pyrrol-5-one BDBM37626 2-(3-methoxy-4-oxidanyl-phenyl)-3-(5-methylfuran-2-yl)carbonyl-4-oxidanyl-1-(2-phenylethyl)-2H-pyrrol-5-one 4-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(5-methylfuran-2-carbonyl)-1-(2-phenylethyl)-2H-pyrrol-5-one 3-hydroxy-5-(4-hydroxy-3-methoxy-phenyl)-4-(5-methyl-2-furoyl)-1-phenethyl-3-pyrrolin-2-one
Inchi Key	ADCXOCIGMYJKFP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H23NO6/c1-15-8-11-19(32-15)23(28)21-22(17-9-10-18(27)20(14-17)31-2)26(25(30)24(21)29)13-12-16-6-4-3-5-7-16/h3-11,14,21-22,27H,12-13H2,1-2H3
PubChem CID	91896293
ChEMBL	N/A
IUPHAR	N/A
BindingDB	37626
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	19700.0 nM	N/A	BindingDB
Ki	12900.0 nM	N/A	BindingDB

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