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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Neuropeptide Y receptor type 2
Species	Homo sapiens (Human)
Gene	NPY2R
Synonym	NPY2-R NPY-Y2 receptor neuropeptide Y receptor type 2 Y2 receptor
Disease	Diabetes Metabolic disorders Obesity
Length	381
Amino acid sequence	MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV
UniProt	P49146
Protein Data Bank	N/A
GPCR-HGmod model	P49146
3D structure model	This predicted structure model is from GPCR-EXP P49146.
BioLiP	N/A
Therapeutic Target Database	T10670
ChEMBL	CHEMBL4018
IUPHAR	306
DrugBank	BE0002419

Ligand

Name	SMR000140824
Molecular formula	C15H12Cl3N3O
IUPAC name	N-(3-chloroanilino)-N'-(2,4-dichlorophenyl)-2-oxopropanimidamide
Molecular weight	356.631
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	5.6
Synonyms	MolPort-019-790-252 AF-886/30751059 CHEMBL1482637 N-(3-chloroanilino)-N''-(2,4-dichlorophenyl)-2-oxopropanimidamide MLS000533426 N'-(3-chlorophenyl)-N-(2,4-dichlorophenyl)-2-oxopropanehydrazonamide BDBM57123 cid_1799038 N-(3-chloroanilino)-N'-(2,4-dichlorophenyl)-2-oxopropanimidamide MolPort-002-176-307 ZINC15985871 AC1LXCO8 N-(3-chloroanilino)-N''-(2,4-dichlorophenyl)-2-keto-propionamidine MCULE-3683405676 N-[(3-chlorophenyl)amino]-N''-(2,4-dichlorophenyl)-2-oxidanylidene-propanimidamide [ Show all ]
Inchi Key	BDIBTQWWJZOREX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H12Cl3N3O/c1-9(22)15(19-14-6-5-11(17)8-13(14)18)21-20-12-4-2-3-10(16)7-12/h2-8,20H,1H3,(H,19,21)
PubChem CID	1799038
ChEMBL	CHEMBL1482637
IUPHAR	N/A
BindingDB	57123
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	21224.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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