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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
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GPCR

Name	Corticotropin-releasing factor receptor 2
Species	Homo sapiens (Human)
Gene	CRHR2
Synonym	CRH-R2 CRH-R-2 CRFR2beta CRFR2alpha CRFR2 CRFR-2 CRF2 receptor CRF-R2 CRF-R-2 CRF 2 receptor Corticotropin-releasing hormone receptor 2 [ Show all ]
Disease	Generalized anxiety disorder Anxiety disorder Congestive heart failure Eating disorders stimulate food consumption anxiety
Length	411
Amino acid sequence	MDAALLHSLLEANCSLALAEELLLDGWGPPLDPEGPYSYCNTTLDQIGTCWPRSAAGALVERPCPEYFNGVKYNTTRNAYRECLENGTWASKINYSQCEPILDDKQRKYDLHYRIALVVNYLGHCVSVAALVAAFLLFLALRSIRCLRNVIHWNLITTFILRNVMWFLLQLVDHEVHESNEVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTERLRKCLFLFIGWCIPFPIIVAWAIGKLYYENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRSAVRKRWHRWQDHHSLRVPMARAMSIPTSPTRISFHSIKQTAAV
UniProt	Q13324
Protein Data Bank	N/A
GPCR-HGmod model	Q13324
3D structure model	This predicted structure model is from GPCR-EXP Q13324.
BioLiP	N/A
Therapeutic Target Database	T11011
ChEMBL	CHEMBL4069
IUPHAR	213
DrugBank	N/A

Ligand

Name	CHEMBL2179195
Molecular formula	C26H37N3O5S
IUPAC name	N-butyl-3-[4-(ethoxymethyl)-2,6-dimethoxyphenyl]-6-methoxy-N-(oxan-4-yl)pyrazolo[5,1-b][1,3]thiazol-7-amine
Molecular weight	503.658
Hydrogen bond acceptor	8
Hydrogen bond donor	0
XlogP	4.8
Synonyms	SCHEMBL3101033 BDBM50398565 MKMSLJYQGXJIQH-UHFFFAOYSA-N N-butyl-3-[4-(ethoxymethyl)-2,6-dimethoxyphenyl]-6-methoxy-N-(tetrahydro-2H-pyran-4-yl)pyrazolo[5,1-b][1,3]thiazole-7-amine
Inchi Key	MKMSLJYQGXJIQH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H37N3O5S/c1-6-8-11-28(19-9-12-34-13-10-19)24-25(32-5)27-29-20(17-35-26(24)29)23-21(30-3)14-18(16-33-7-2)15-22(23)31-4/h14-15,17,19H,6-13,16H2,1-5H3
PubChem CID	57912459
ChEMBL	CHEMBL2179195
IUPHAR	N/A
BindingDB	50398565
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<10000.0 nM	PMID22971011	BindingDB,ChEMBL

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