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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	G-protein coupled receptor homolog US28
Species	Human cytomegalovirus (strain AD169) (HHV-5)
Gene	US28
Synonym	HHRF3
Disease	N/A for non-human GPCRs
Length	354
Amino acid sequence	MTPTTTTAELTTEFDYDEDATPCVFTDVLNQSKPVTLFLYGVVFLFGSIGNFLVIFTITWRRRIQCSGDVYFINLAAADLLFVCTLPLWMQYLLDHNSLASVPCTLLTACFYVAMFASLCFITEIALDRYYAIVYMRYRPVKQACLFSIFWWIFAVIIAIPHFMVVTKKDNQCMTDYDYLEVSYPIILNVELMLGAFVIPLSVISYCYYRISRIVAVSQSRHKGRIVRVLIAVVLVFIIFWLPYHLTLFVDTLKLLKWISSSCEFERSLKRALILTESLAFCHCCLNPLLYVFVGTKFRQELHCLLAEFRQRLFSRDVSWYHSMSFSRRSSPSRRETSSDTLSDEVCRVSQIIP
UniProt	P69332
Protein Data Bank	4xt1
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 4xt1.
BioLiP	BL0309402,BL0309403
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4259
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	VUF-2274
Molecular formula	C28H29ClN2O
IUPAC name	5-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-2,2-diphenylpentanenitrile
Molecular weight	445.003
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	5.6
Synonyms	1-Piperidinepentanenitrile, 4-(4-chlorophenyl)-4-hydroxy-a,a-diphenyl- BDBM50027216 5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentanenitrile L000124 A1-01967 5-(4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl)-2,2-diphenylpentanenitrile 5-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-2,2-diphenyl-pentanenitrile NCGC00378719-01 AKOS024256779 ZINC3991118 5-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-2,2-diphenylpentanenitrile CHEMBL34166 SCHEMBL8891715 [ Show all ]
Inchi Key	MEEJEEVTIVAOJP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H29ClN2O/c29-26-14-12-25(13-15-26)28(32)17-20-31(21-18-28)19-7-16-27(22-30,23-8-3-1-4-9-23)24-10-5-2-6-11-24/h1-6,8-15,32H,7,16-21H2
PubChem CID	9889700
ChEMBL	CHEMBL34166
IUPHAR	N/A
BindingDB	50027216
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	3200.0 nM	PMID16190772	BindingDB,ChEMBL
EC50	4500.0 nM	PMID25052428	ChEMBL
EC50	4570.88 nM	PMID25052428	ChEMBL
Efficacy	-22.0 %	PMID25052428	ChEMBL
IC50	9300.0 nM	PMID16190772	BindingDB,ChEMBL

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