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Name | Histamine H4 receptor |
---|---|
Species | Homo sapiens (Human) |
Gene | HRH4 |
Synonym | Pfi-013 SP9144 HH4R H4R H4 receptor [ Show all ] |
Disease | Allergic rhinitis Asthma Inflammatory disease Rheumatoid arthritis |
Length | 390 |
Amino acid sequence | MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS |
UniProt | Q9H3N8 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q9H3N8 |
3D structure model | This predicted structure model is from GPCR-EXP Q9H3N8. |
BioLiP | N/A |
Therapeutic Target Database | T26500 |
ChEMBL | CHEMBL3759 |
IUPHAR | 265 |
DrugBank | BE0000146 |
Name | CHEMBL494667 |
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Molecular formula | C12H17N7 |
IUPAC name | 4-(1H-imidazol-5-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine |
Molecular weight | 259.317 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 2 |
XlogP | 0.0 |
Synonyms | SCHEMBL2167051 |
Inchi Key | MCSLSGYTPAVGEY-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C12H17N7/c1-18-2-4-19(5-3-18)11-6-9(16-12(13)17-11)10-7-14-8-15-10/h6-8H,2-5H2,1H3,(H,14,15)(H2,13,16,17) |
PubChem CID | 25131559 |
ChEMBL | CHEMBL494667 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 16.22 nM | PMID18811133 | ChEMBL |
Efficacy | 41.0 % | PMID18811133 | ChEMBL |
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