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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Adenosine receptor A3
Species	Rattus norvegicus (Rat)
Gene	Adora3
Synonym	A3 receptor A3AR Adenosine receptor A3 ARA3 TGPCR1
Disease	N/A for non-human GPCRs
Length	320
Amino acid sequence	MKANNTTTSALWLQITYITMEAAIGLCAVVGNMLVIWVVKLNRTLRTTTFYFIVSLALADIAVGVLVIPLAIAVSLEVQMHFYACLFMSCVLLVFTHASIMSLLAIAVDRYLRVKLTVRYRTVTTQRRIWLFLGLCWLVSFLVGLTPMFGWNRKVTLELSQNSSTLSCHFRSVVGLDYMVFFSFITWILIPLVVMCIIYLDIFYIIRNKLSQNLTGFRETRAFYGREFKTAKSLFLVLFLFALCWLPLSIINFVSYFNVKIPEIAMCLGILLSHANSMMNPIVYACKIKKFKETYFVILRACRLCQTSDSLDSNLEQTTE
UniProt	P28647
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3360
IUPHAR	21
DrugBank	N/A

Ligand

Name	CHEMBL2112597
Molecular formula	C10H14N6O
IUPAC name	(1R,2R)-2-(2,6-diaminopurin-9-yl)cyclopentan-1-ol
Molecular weight	234.263
Hydrogen bond acceptor	6
Hydrogen bond donor	3
XlogP	-0.1
Synonyms	BDBM50454087
Inchi Key	BCHSDZWYFZFOEU-PHDIDXHHSA-N
Inchi ID	InChI=1S/C10H14N6O/c11-8-7-9(15-10(12)14-8)16(4-13-7)5-2-1-3-6(5)17/h4-6,17H,1-3H2,(H4,11,12,14,15)/t5-,6-/m1/s1
PubChem CID	10421535
ChEMBL	CHEMBL2112597
IUPHAR	N/A
BindingDB	50454087
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	199000.0 nM	PMID7707320	BindingDB,ChEMBL

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