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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H4 receptor
Species	Homo sapiens (Human)
Gene	HRH4
Synonym	Pfi-013 SP9144 HH4R H4R H4 receptor GPRv53 GPCR105 G-protein coupled receptor 105 AXOR35 [ Show all ]
Disease	Allergic rhinitis Asthma Inflammatory disease Rheumatoid arthritis
Length	390
Amino acid sequence	MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
UniProt	Q9H3N8
Protein Data Bank	N/A
GPCR-HGmod model	Q9H3N8
3D structure model	This predicted structure model is from GPCR-EXP Q9H3N8.
BioLiP	N/A
Therapeutic Target Database	T26500
ChEMBL	CHEMBL3759
IUPHAR	265
DrugBank	BE0000146

Ligand

Name	SCHEMBL603530
Molecular formula	C18H23N5
IUPAC name	8-phenyl-4-piperazin-1-yl-5,6,7,8-tetrahydroquinazolin-2-amine
Molecular weight	309.417
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	2.3
Synonyms	CHEMBL1077256 8-phenyl-4-(piperazin-1-yl)-5,6,7,8-tetrahydroquinazolin-2-amine LUZQAKHWJIHCHV-UHFFFAOYSA-N
Inchi Key	LUZQAKHWJIHCHV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H23N5/c19-18-21-16-14(13-5-2-1-3-6-13)7-4-8-15(16)17(22-18)23-11-9-20-10-12-23/h1-3,5-6,14,20H,4,7-12H2,(H2,19,21,22)
PubChem CID	44466872
ChEMBL	CHEMBL1077256
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
pKb	7.52 -	PMID20171098	ChEMBL

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