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GPCR

Name	Delta-type opioid receptor
Species	Homo sapiens (Human)
Gene	OPRD1
Synonym	D-OR-1 DOR opioid receptor OP1 DOP DOPr DOR-1 Delta receptor [ Show all ]
Disease	Cough Overactive bladder disorder Bladder disease Moderate-to-severe pain Diarrhea-predominant IBS Major depressive disorder Urinary incontinence Rheumatoid arthritis Premature ejaculation Pain Acute migraine Ischemic heart diseases Acute nonspecific diarrhea; Chronic diarrhea associated with inflammatory bowel disease Alcohol use disorders Anxiety disorder [ Show all ]
Length	372
Amino acid sequence	MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
UniProt	P41143
Protein Data Bank	4rwd, 4rwa, 4n6h
GPCR-HGmod model	P41143
3D structure model	This structure is from PDB ID 4rwd.
BioLiP	BL0303696,BL0303697, BL0265712, BL0265705,BL0265706,BL0265707,, BL0303699,BL0303701, BL0303698,BL0303700
Therapeutic Target Database	T58992
ChEMBL	CHEMBL236
IUPHAR	317
DrugBank	BE0000420

Ligand

Name	HYDROCODONE
Molecular formula	C18H21NO3
IUPAC name	(4R,4aR,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
Molecular weight	299.37
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	2.2
Synonyms	125-29-1 Morphinan-6-one, 4,5-epoxy-3-methoxy-17-methyl-, (5alpha)- (9CI) 4,5alpha-Epoxy-3-methoxy-17-methylmorphinan-6-one NCGC00159317-02 9007-52-7 opioid1 CHEMBL1457 ZINC1280665 DEA No. 9193 GTPL7081 Hydrocodon Hydrocodone prodrug (Bio-MD/immediate release, pain), PharmacoFore Hydrocone KP-201 hydrocodone prodrug Lortab (TN) 3-methoxy-17-methyl-4,5alpha-epoxymorphinan-6-one Morphinan-6-one, 4,5alpha-epoxy-3-methoxy-17-methyl- (8CI) Norgan (TN) Bekadid SCHEMBL2987 D08045 Dicodid (TN) HSDB 3097 Hydrocodone 0.1 mg/ml in Methanol Hydrocodone prodrug (oral, pain), KemPharm Hydrovo (TN) (-)-Dihydrocodeinone Morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl- 4,5.alpha.-Epoxy-3-methoxy-17-methylmorphinan-6-one Morphinan-6-one,5.alpha.-epoxy-3-methoxy-17-methyl- 6YKS4Y3WQ7 NSC-19044 CHEBI:5779 UNII-6YKS4Y3WQ7 Duodin (TN) Hycomine (TN) Hydrocodone polistirex [USAN] Hydrocodonum [INN-Latin] Kolikodol (TN) (5alpha)-17-methyl-3-(methyloxy)-4,5-epoxymorphinan-6-one 1469752-80-4 Morphinan-6-one, 4,5-epoxy-3-methoxy-17-methyl-, (5alpha)-(9CI) 4-27-00-03580 (Beilstein Handbook Reference) NCGC00159317-03 Anexsia (TN) Orthoxycol (TN) Codeinone, dihydro- Zohydro DICO hidrocodona Hydrocodone prodrug (Bio-MD/MPAR/oral, pain), PharmacoFore Hydroconum LLPOLZWFYMWNKH-CMKMFDCUSA-N LS-92156 34195-34-1 (tartrate (1:1), hydrate (2:5)) Morphinan-6-one, 4,5alpha-epoxy-3-methoxy-17-methyl-(8CI) 50678-79-0 Novahistex (TN) BRN 0094193 Symtan (TN) D0C2DS Dihydrocodeinone Hycet (TN) Hydrocodone 1.0 mg/ml in Methanol Hydrocodone [INN:BAN] Idrocodone (1S,5R,13R,17R)-10-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0;{1,13}.0;{5,17}.0;{7,18}]octadeca-7(18),8,10-trien-14-one Morphinan-6-one, 4,5-epoxy-3-methoxy-17-methyl-, (5alpha)- 4,5alpha-epoxy-3-methoxy-17-methyl-morphinan-6-one Multacodin NSC19044 WLN: T B6566 B6/CO 4ABBC R BX FV HO PN GHT&&TTJ JO1 P1 DB00956 EINECS 204-733-9 Hydrocodeinonebitartrate Hydrocodone prodrug (Bio-MD, pain), PharmacoFore Hydrocon KP-201 1037-91-8 17-methyl-4,5alpha-epoxy-3-methoxymorphinan-6-one Morphinan-6-one, 4,5alpha-epoxy-3-methoxy-17-methyl- 4aH-8,5-bcd]furan-5-(6H)-one, 7,7a,8,9-tetrahydro-3-methoxy-12-methyl- Norco (TN) BDBM50386689 PF-06 program Codinovo Dicodid Hidrocodona [INN-Spanish] Hydrocodone (INN) Hydrocodone prodrug (Bio-MD/MPAR/oral/immediate release, pain), PharmacoFore Hydrokon (TN) Lorcet (TN) Mercodinone (TN) 4,5-alpha-Epoxy-3-methoxy-17-methylmorphinan-6-one Morphinan-6-one,5-epoxy-3-methoxy-17-methyl-, (5.alpha.)- 6-Oxo-3-methoxy-N-methyl-4,5-epoxymorphinan NSC 19044 C08024 Synkonin (TN) D0X5KF DTXSID8023131 Hycodan (TN) Hydrocodone polistirex Hydrocodonum Idrocodone [DCIT] (4R,4aR,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one [ Show all ]
Inchi Key	LLPOLZWFYMWNKH-CMKMFDCUSA-N
Inchi ID	InChI=1S/C18H21NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3,6,11-12,17H,4-5,7-9H2,1-2H3/t11-,12+,17-,18-/m0/s1
PubChem CID	5284569
ChEMBL	CHEMBL1457
IUPHAR	7081
BindingDB	50386689
DrugBank	DB00956
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank
Inhibition	37.0 %	PMID22439881	ChEMBL

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