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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H2 receptor
Species	Rattus norvegicus (Rat)
Gene	Hrh2
Synonym	gastric receptor I H2 receptor H2R HH2R
Disease	N/A for non-human GPCRs
Length	358
Amino acid sequence	MEPNGTVHSCCLDSMALKVTISVVLTTLILITIAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVLPFSAIYQLSFTWSFGHVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLVTPVRVAISLVFIWVISITLSFLSIHLGWNSRNGTRGGNDTFKCKVQVNEVYGLVDGLVTFYLPLLIMCVTYYRIFKIAREQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEAVEGIVLWLGYANSALNPILYAALNRDFRTAYQQLFHCKFASHNSHKTSLRLNNSLLPRSQSREGRWQEEKPLKLQVWSGTELTHPQGNPIR
UniProt	P25102
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4654
IUPHAR	263
DrugBank	N/A

Ligand

Name	Amthamine
Molecular formula	C6H11N3S
IUPAC name	5-(2-aminoethyl)-4-methyl-1,3-thiazol-2-amine
Molecular weight	157.235
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	0.4
Synonyms	CHEMBL293762 L000107 5-Thiazoleethanamine, 2-amino-4-methyl- DTXSID80162039 RL01758 2-Amino-5-(2-aminoethyl)-4-methylthiazole CHEBI:92694 J-007652 Tocris-0668 5-(2-aminoethyl)-4-methyl-1,3-thiazol-2-amine CTK8E9579 NCGC00024719-01 142437-67-0 AC1L2QR3 FT-0694778 RT-011284 BDBM22881 KB-47389 ZINC5099 5-(2-aminoethyl)-4-methylthiazol-2-amine D0I5CT NCGC00024719-02 2-AMINO-4-METHYLTHIAZOLE-5-ETHANAMINE AKOS006271424 BRD-K39670393-303-01-3 GTPL4025 SCHEMBL400272 [ Show all ]
Inchi Key	LHVRFUVVRXGZPV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C6H11N3S/c1-4-5(2-3-7)10-6(8)9-4/h2-3,7H2,1H3,(H2,8,9)
PubChem CID	126688
ChEMBL	CHEMBL293762
IUPHAR	4025
BindingDB	22881
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kd	11481.5 nM	Bioorg. Med. Chem. Lett., (1994) 4:16:1913	ChEMBL
Kd	11482.0 nM	N/A	BindingDB

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