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GPCR

Name	Neuropeptide Y receptor type 2
Species	Homo sapiens (Human)
Gene	NPY2R
Synonym	NPY2-R NPY-Y2 receptor neuropeptide Y receptor type 2 Y2 receptor
Disease	Diabetes Metabolic disorders Obesity
Length	381
Amino acid sequence	MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV
UniProt	P49146
Protein Data Bank	N/A
GPCR-HGmod model	P49146
3D structure model	This predicted structure model is from GPCR-EXP P49146.
BioLiP	N/A
Therapeutic Target Database	T10670
ChEMBL	CHEMBL4018
IUPHAR	306
DrugBank	BE0002419

Ligand

Name	MLS000807054
Molecular formula	C12H17NO6
IUPAC name	3-(furan-2-ylmethylamino)-4-(2-methoxyethoxy)-4-oxobutanoic acid
Molecular weight	271.269
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	-2.6
Synonyms	2-[(Furan-2-ylmethyl)-amino]-succinic acid 1-(2-methoxy-ethyl) ester AC1MME3R 3-(2-furfurylamino)-4-keto-4-(2-methoxyethoxy)butyric acid STK087237 3-[(furan-2-ylmethyl)amino]-4-(2-methoxyethoxy)-4-oxobutanoic acid (non-preferred name) HMS2750G05 3-((furan-2-ylmethyl)amino)-4-(2-methoxyethoxy)-4-oxobutanoic acid AKOS005393911 MolPort-002-588-829 3-(furan-2-ylmethylamino)-4-(2-methoxyethoxy)-4-oxidanylidene-butanoic acid CHEMBL1419048 MCULE-8978408436 3-(2-furanylmethylamino)-4-(2-methoxyethoxy)-4-oxobutanoic acid BDBM46522 SMR000414868 3-(furan-2-ylmethylamino)-4-(2-methoxyethoxy)-4-oxobutanoic acid cid_3259549 [ Show all ]
Inchi Key	AYWWNXNKVVOLRI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C12H17NO6/c1-17-5-6-19-12(16)10(7-11(14)15)13-8-9-3-2-4-18-9/h2-4,10,13H,5-8H2,1H3,(H,14,15)
PubChem CID	3259549
ChEMBL	CHEMBL1419048
IUPHAR	N/A
BindingDB	46522
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<35430.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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